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Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo.

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Date
2018-07
Authors
Chhatbar, Pratik Y
Kautz, Steven A
Takacs, Istvan
Rowland, Nathan C
Revuelta, Gonzalo J
George, Mark S
Bikson, Marom
Feng, Wuwei
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Abstract
BACKGROUND:Transcranial direct current stimulation (tDCS) is a promising brain modulation technique for several disease conditions. With this technique, some portion of the current penetrates through the scalp to the cortex and modulates cortical excitability, but a recent human cadaver study questions the amount. This insufficient intracerebral penetration of currents may partially explain the inconsistent and mixed results in tDCS studies to date. Experimental validation of a transcranial alternating current stimulation-generated electric field (EF) in vivo has been performed on the cortical (using electrocorticography, ECoG, electrodes), subcortical (using stereo electroencephalography, SEEG, electrodes) and deeper thalamic/subthalamic levels (using DBS electrodes). However, tDCS-generated EF measurements have never been attempted. OBJECTIVE:We aimed to demonstrate that tDCS generates biologically relevant EF as deep as the subthalamic level in vivo. METHODS:Patients with movement disorders who have implanted deep brain stimulation (DBS) electrodes serve as a natural experimental model for thalamic/subthalamic recordings of tDCS-generated EF. We measured voltage changes from DBS electrodes and body resistance from tDCS electrodes in three subjects while applying direct current to the scalp at 2 mA and 4 mA over two tDCS montages. RESULTS:Voltage changes at the level of deep nuclei changed proportionally with the level of applied current and varied with different tDCS montages. CONCLUSIONS:Our findings suggest that scalp-applied tDCS generates biologically relevant EF. Incorporation of these experimental results may improve finite element analysis (FEA)-based models.
Type
Journal article
Subject
Thalamus
Humans
Electromagnetic Fields
Adult
Female
Male
Brain Waves
Transcranial Direct Current Stimulation
Permalink
https://hdl.handle.net/10161/19125
Published Version (Please cite this version)
10.1016/j.brs.2018.03.006
Publication Info
Chhatbar, Pratik Y; Kautz, Steven A; Takacs, Istvan; Rowland, Nathan C; Revuelta, Gonzalo J; George, Mark S; ... Feng, Wuwei (2018). Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo. Brain stimulation, 11(4). pp. 727-733. 10.1016/j.brs.2018.03.006. Retrieved from https://hdl.handle.net/10161/19125.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Chhatbar

Pratik Yashvant Chhatbar

Adjunct Assistant Professor in the Department of Neurology
Neuromodulation / Neuroprosthetics / Upcoming technologies
Feng

Wuwei Feng

Professor of Neurology
Wayne Feng is the Chief of Division of Stroke & Vascular Neurology, Medical Director of Duke Comprehensive Stroke Center, and Tenured Profess of Neurology and Biomedical Engineering at Duke University School of Medicine. Dr. Feng is a board-certified vascular neurologist as well as a physician scientist. His research portfolios include developing imaging biomarker for post-stroke motor outcomes prediction, and use of non-invasive brain stimulation tools, such as, transcranial direct curre
Alphabetical list of authors with Scholars@Duke profiles.
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