Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
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Published Version (Please cite this version)10.1038/s41467-019-11618-7
Publication InfoChen, Ming; Han, Tao; Jiang, Shulong; Zheng, Hong; Yin, Qing; Xie, Mengyu; ... Wan, Lixin (2019). Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. Nature Communications, 10(1). 10.1038/s41467-019-11618-7. Retrieved from https://hdl.handle.net/10161/19230.
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Assistant Professor in Pathology
Our laboratory is interested in understanding the molecular and genetic events underlying cancer progression and metastasis. The focus of our work is a series of genetically engineered mouse models that faithfully recapitulate human disease. Using a combination of mouse genetics, omics technologies, cross-species analyses and in vitro approaches, we aim to identify cancer cell–intrinsic and –extrinsic mechanisms driving metastatic cancer progression, with a long