Correlation of pre-operative imaging characteristics with donor outcomes and operative difficulty in laparoscopic donor nephrectomy.
Abstract
This study aimed to understand the relationship of pre-operative measurements and
risk factors on operative time and outcomes of laparoscopic donor nephrectomy. 242
kidney donors between 2010 and 2017 were identified. Patient's demographic, anthropomorphic
and operative characteristics were abstracted from the electronic medical record.
Glomerular filtration rates (GFR) were documented before surgery, within 24 hours,
6, 12 and 24 months after surgery. Standard radiological measures and kidney volumes,
subcutaneous and perinephric fat thicknesses were assessed by three radiologists.
Data were analyzed using standard statistical measures. There was significant correlation
between cranio-caudal and latero-lateral diameters (p<0.0001) and kidney volume. The
left kidney was transplanted in 92.6% of cases and the larger kidney in 69.2%. Kidney
choice (smaller vs larger) had no statistically significant impact on the rate of
change of donor kidney function over time adjusting for age, sex and race (p=0.61).
Perinephric fat thickness (+4.08 min) and surgery after 2011 were significantly correlated
with operative time (p≤0.01). In conclusion, cranio-caudal diameters can be used as
a surrogate measure for volume in the majority of donors. Size may not be a decisive
factor for long-term donor kidney function. Perinephric fat around the donor kidney
should be reported to facilitate operative planning.
Type
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https://hdl.handle.net/10161/19352Published Version (Please cite this version)
10.1111/ajt.15608Publication Info
Schwartz, Fides R; Shaw, Brian I; Lerebours, Reginald; Vernuccio, Federica; Rigiroli,
Francesca; Gonzalez, Fernando; ... Ravindra, Kadiyala (2019). Correlation of pre-operative imaging characteristics with donor outcomes and operative
difficulty in laparoscopic donor nephrectomy. American journal of transplantation : official journal of the American Society of
Transplantation and the American Society of Transplant Surgeons. 10.1111/ajt.15608. Retrieved from https://hdl.handle.net/10161/19352.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Reginald (Gino) Lerebours
Biostatistician II
Education: Masters Degree, Biostatistics. Harvard University. 2017Bachelors Degree,
Statistics. North Carolina State University. 2015Overview: Gino currently collaborates
with researchers, residents, and clinicians in the Departments of Surgery, Radiology
and Infectious Diseases. His main research interests and experience are in statistical
programming, data management, statistical modeling, statistical consulting and statistical
education.
Sheng Luo
Professor of Biostatistics & Bioinformatics
Daniele Marin
Associate Professor of Radiology
Liver Imaging Dual Energy CT CT Protocol Optimization Dose Reduction Strategies for
Abdominal CT Applications
Kadiyala Venkata Ravindra
Professor of Surgery
Aparna Sharad Rege
Clinical Associate in the Department of Surgery
Fides Regina Schwartz
Research Associate, Senior
My passion is for radiology research. As a resident, I was invited to present my research
at international conferences (Journees Fracophones de la Radiologie, Paris, European
Congress of Radiology, RSNA) and these experiences inspired me to focus on research.
I completed medical school in Heidelberg, Germany and Pamplona, Spain (through the
ERASMUS scholarship program). During that time, I also completed internships in California,
Bahrein, Barcelona and New Orleans). I completed my radiolo
Brian Shaw
House Staff
Federica Vernuccio
Visiting Associate in the Department of Radiology
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