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The expanded role of fatty acid metabolism in cancer: new aspects and targets
Abstract
<jats:title>Abstract</jats:title>
<jats:p>Cancer cells undergo metabolic reprogramming to support cell proliferation,
growth, and dissemination. Alterations in lipid metabolism, and specifically the uptake
and synthesis of fatty acids (FAs), comprise one well-documented aspect of this reprogramming.
Recent studies have revealed an expanded range of roles played by FA in promoting
the aggressiveness of cancer while simultaneously identifying new potential targets
for cancer therapy. This article provides a brief review of these advances in our
understanding of FA metabolism in cancer, highlighting both recent discoveries and
the inherent challenges caused by the metabolic plasticity of cancer cells in targeting
lipid metabolism for cancer therapy.</jats:p>
Type
Journal articlePermalink
https://hdl.handle.net/10161/19408Published Version (Please cite this version)
10.1093/pcmedi/pbz017Publication Info
(2019). The expanded role of fatty acid metabolism in cancer: new aspects and targets. Precision Clinical Medicine, 2(3). pp. 183-191. 10.1093/pcmedi/pbz017. Retrieved from https://hdl.handle.net/10161/19408.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Ming Chen
Associate Professor in Pathology
Our laboratory is interested in understanding the molecular and genetic events underlying
cancer progression and metastasis. The focus of our work is a series of genetically
engineered mouse models that faithfully recapitulate human disease. Using a combination
of mouse genetics, omics technologies, cross-species analyses and in vitro approaches,
we aim to identify cancer cell–intrinsic and –extrinsic mechanisms driving
metastatic cancer progression, with a long
Jiaoti Huang
The Johnston-West Endowed Department Chair of Pathology
I am a physician-scientist with clinical expertise in the pathologic diagnosis of
genitourinary tumors including tumors of the prostate, bladder, kidney and testis.
Another area of interest is gynecologic tumors. In my research laboratory we study
prostate cancer, focusing on molecular mechanisms of carcinogenesis and tumor progression,
as well as biomarkers, imaging and novel therapeutic strategies. In addition to patient
care and research, I am also passionate about education. I have trained n
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