Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.
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[This corrects the article DOI: 10.1371/journal.ppat.1008026.].
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https://hdl.handle.net/10161/19718Published Version (Please cite this version)
10.1371/journal.ppat.1008200Publication Info
(2019). Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity
for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.
PLoS pathogens, 15(12). pp. e1008200. 10.1371/journal.ppat.1008200. Retrieved from https://hdl.handle.net/10161/19718.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Priyamvada Acharya
Associate Professor in Surgery
S. Munir Alam
Professor in Medicine
Research Interests.
The Alam laboratory’s primary research is focused on understanding the biophysical
properties of antigen-antibody binding and the molecular events of early B cell activation
using the HIV-1 broadly neutralizing antibody (bnAb) lineage models. We are studying
how HIV-1 Envelope proteins of varying affinities are sensed by B cells expressing
HIV-1 bnAbs or their germline antigen receptors and initiate early signaling events
for their activation. In the lon
Mattia Bonsignori
Associate Professor in Medicine
HIV vaccine development Study of B-cell immune responses in HIV positive individuals
Determination of correlates of protective immunity to HIV Induction of broadly neutralizing
antibodies to HIV Development of multiplex functional assays for the evaluation at
a single-cell level of B-cell responses to vaccinations, infections and in vitro stimulation
Epidemiology and characterization of bacterial resistance determinants (past) </do
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.
Mario-Juan Borgnia
Adjunct Professor in the Department of Biochemistry
Barton Ford Haynes
Frederic M. Hanes Distinguished Professor of Medicine
The Haynes lab is studying host innate and adaptive immune responses to the human
immunodeficiency virus (HIV), tuberculosis (TB), and influenza in order to find the
enabling technology to make preventive vaccines against these three major infectious
diseases. Mucosal Immune Responses in Acute HIV Infection The Haynes lab is working
to determine why broadly neutralizing antibodies are rarely made in acute HIV infection
(AHI), currently a major obstacle in the de
Rory Henderson
Assistant Professor in Medicine
Celia Crane LaBranche
Associate Professor Emeritus
David Charles Montefiori
Professor in Surgery
Dr. Montefiori is Professor and Director of the Laboratory for HIV and COVID-19 Vaccine
Research & Development in the Department of Surgery, Division of Surgical Sciences
at Duke University Medical Center. His major research interests are viral immunology
and HIV and COVID-19 vaccine development, with a special emphasis on neutralizing
antibodies. Multiple aspects of HIV-1 neutralizing antibodies are studied in his laboratory,
including mechanisms of neutralization and escape,
Kevin O'Neil Saunders
Associate Professor in Surgery
The Saunders laboratory aims to understand the immunology of HIV-1 antibodies and
the molecular biology of their interaction with HIV-1 envelope (Env) glycoprotein.
Our overall goal is to develop protective antibody-based vaccines; therefore, the
laboratory has two sections–antibody repertoire analysis and immunogen design.
Our research premise is that vaccine-elicited antibodies will broadly neutralize HIV-1
if they can bind directly to the host glycans on Env. However, Env glycans are
Kevin J Wiehe
Associate Professor in Medicine
Wilton Bryan Williams
Associate Professor in Surgery
Dr. Williams completed a PhD in Biomedical Sciences (Immunology and Microbiology)
from the University of Florida and did his postdoctoral work in the laboratory of
Dr. Barton Haynes at the Duke Human Vaccine Institute (DHVI). The key goals of HIV
vaccine development are to define the host-virus events during natural HIV infection
that lead to the induction of broadly neutralizing antibodies, and to recreate those
events with a vaccine. As a junior faculty member in the DHVI, Dr. W
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