Calcium Signaling and Cardiac Arrhythmias.
Abstract
There has been a significant progress in our understanding of the molecular mechanisms
by which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing
list of inherited gene defects can cause potentially lethal cardiac arrhythmia syndromes,
including catecholaminergic polymorphic ventricular tachycardia, congenital long QT
syndrome, and hypertrophic cardiomyopathy. In addition, acquired deficits of multiple
Ca2+-handling proteins can contribute to the pathogenesis of arrhythmias in patients
with various types of heart disease. In this review article, we will first review
the key role of Ca2+ in normal cardiac function-in particular, excitation-contraction
coupling and normal electric rhythms. The functional involvement of Ca2+ in distinct
arrhythmia mechanisms will be discussed, followed by various inherited arrhythmia
syndromes caused by mutations in Ca2+-handling proteins. Finally, we will discuss
how changes in the expression of regulation of Ca2+ channels and transporters can
cause acquired arrhythmias, and how these mechanisms might be targeted for therapeutic
purposes.
Type
Journal articleSubject
Sarcoplasmic ReticulumHeart Conduction System
Myocytes, Cardiac
Animals
Humans
Ryanodine Receptor Calcium Release Channel
Calcium Signaling
Arrhythmias, Cardiac
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https://hdl.handle.net/10161/20307Published Version (Please cite this version)
10.1161/CIRCRESAHA.117.310083Publication Info
Landstrom, AP; Dobrev, D; & Wehrens, XHT (2017). Calcium Signaling and Cardiac Arrhythmias. Circulation research, 120(12). pp. 1969-1993. 10.1161/CIRCRESAHA.117.310083. Retrieved from https://hdl.handle.net/10161/20307.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Andrew Paul Landstrom
Associate Professor of Pediatrics
Dr. Landstrom is a physician scientist who specializes in the care of children and
young adults with arrhythmias, heritable cardiovascular diseases, and sudden unexplained
death syndromes. As a clinician, he is trained in pediatric cardiology with a focus
on arrhythmias and genetic diseases of the heart. He specializes in caring for patients
with heritable arrhythmia (channelopathies) such as long QT syndrome, Brugada syndrome,
catecholaminergic polymorphic ventricular tachycardia,

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