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Calcium Signaling and Cardiac Arrhythmias.

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Date
2017-06
Authors
Landstrom, AP
Dobrev, D
Wehrens, XHT
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Abstract
There has been a significant progress in our understanding of the molecular mechanisms by which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of inherited gene defects can cause potentially lethal cardiac arrhythmia syndromes, including catecholaminergic polymorphic ventricular tachycardia, congenital long QT syndrome, and hypertrophic cardiomyopathy. In addition, acquired deficits of multiple Ca2+-handling proteins can contribute to the pathogenesis of arrhythmias in patients with various types of heart disease. In this review article, we will first review the key role of Ca2+ in normal cardiac function-in particular, excitation-contraction coupling and normal electric rhythms. The functional involvement of Ca2+ in distinct arrhythmia mechanisms will be discussed, followed by various inherited arrhythmia syndromes caused by mutations in Ca2+-handling proteins. Finally, we will discuss how changes in the expression of regulation of Ca2+ channels and transporters can cause acquired arrhythmias, and how these mechanisms might be targeted for therapeutic purposes.
Type
Journal article
Subject
Sarcoplasmic Reticulum
Heart Conduction System
Myocytes, Cardiac
Animals
Humans
Ryanodine Receptor Calcium Release Channel
Calcium Signaling
Arrhythmias, Cardiac
Permalink
https://hdl.handle.net/10161/20307
Published Version (Please cite this version)
10.1161/CIRCRESAHA.117.310083
Publication Info
Landstrom, AP; Dobrev, D; & Wehrens, XHT (2017). Calcium Signaling and Cardiac Arrhythmias. Circulation research, 120(12). pp. 1969-1993. 10.1161/CIRCRESAHA.117.310083. Retrieved from https://hdl.handle.net/10161/20307.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Landstrom

Andrew Paul Landstrom

Associate Professor of Pediatrics
Dr. Landstrom is a physician scientist who specializes in the care of children and young adults with arrhythmias, heritable cardiovascular diseases, and sudden unexplained death syndromes. As a clinician, he is trained in pediatric cardiology with a focus on arrhythmias and genetic diseases of the heart.  He specializes in caring for patients with heritable arrhythmia (channelopathies) such as long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia,
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