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Preclinical and Coclinical Studies in Prostate Cancer.

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Date
2018-04-02
Authors
Chen, Ming
Pandolfi, Pier Paolo
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Abstract
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably succumb to their disease. Thus there remains a pressing need for preclinical testing of new drugs and drug combinations for late-stage prostate cancer (PCa). Insights from the mCRPC genomic landscape have revealed that, in addition to sustained androgen receptor (AR) signaling, there are other actionable molecular alterations and distinct molecular subclasses of PCa; however, the rate at which this knowledge translates into patient care via current preclinical testing is painfully slow and inefficient. Here, we will highlight the issues involved and discuss a new translational platform, "the co-clinical trial project," to expedite current preclinical studies and optimize clinical trial and experimental drug testing. With this platform, in vivo preclinical and early clinical studies are closely aligned, enabling in vivo testing of drugs using genetically engineered mouse models (GEMMs) in defined genetic contexts to personalize individual therapies. We will discuss the principles and essential components of this novel paradigm, representative success stories and future therapeutic options for mCRPC that should be explored.
Type
Journal article
Subject
Animals
Humans
Mice
Disease Models, Animal
Receptors, Androgen
Antineoplastic Combined Chemotherapy Protocols
Drug Resistance, Neoplasm
Male
Clinical Trials as Topic
Prostatic Neoplasms, Castration-Resistant
Antineoplastic Agents, Immunological
Permalink
https://hdl.handle.net/10161/20377
Published Version (Please cite this version)
10.1101/cshperspect.a030544
Publication Info
Chen, Ming; & Pandolfi, Pier Paolo (2018). Preclinical and Coclinical Studies in Prostate Cancer. Cold Spring Harbor perspectives in medicine, 8(4). pp. a030544-a030544. 10.1101/cshperspect.a030544. Retrieved from https://hdl.handle.net/10161/20377.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Chen

Ming Chen

Associate Professor in Pathology
Our laboratory is interested in understanding the molecular and genetic events underlying cancer progression and metastasis. The focus of our work is a series of genetically engineered mouse models that faithfully recapitulate human disease. Using a combination of mouse genetics, omics technologies, cross-species analyses and in vitro approaches, we aim to identify cancer cell–intrinsic and –extrinsic mechanisms driving metastatic cancer progression, with a long
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