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Comparative Approach to the Temporo-Spatial Organization of the Tumor Microenvironment

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Date
2019-11-07
Authors
Langsten, KL
Kim, JH
Sarver, AL
Dewhirst, M
Modiano, JF
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Abstract
© Copyright © 2019 Langsten, Kim, Sarver, Dewhirst and Modiano. The complex ecosystem in which tumor cells reside and interact, termed the tumor microenvironment (TME), encompasses all cells and components associated with a neoplasm that are not transformed cells. Interactions between tumor cells and the TME are complex and fluid, with each facet coercing the other, largely, into promoting tumor progression. While the TME in humans is relatively well-described, a compilation and comparison of the TME in our canine counterparts has not yet been described. As is the case in humans, dog tumors exhibit greater heterogeneity than what is appreciated in laboratory animal models, although the current level of knowledge on similarities and differences in the TME between dogs and humans, and the practical implications of that information, require further investigation. This review summarizes some of the complexities of the human and mouse TME and interjects with what is known in the dog, relaying the information in the context of the temporo-spatial organization of the TME. To the authors' knowledge, the development of the TME over space and time has not been widely discussed, and a comprehensive review of the canine TME has not been done. The specific topics covered in this review include cellular invasion and interactions within the TME, metabolic derangements in the TME and vascular invasion, and the involvement of the TME in tumor spread and metastasis.
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Journal article
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https://hdl.handle.net/10161/20610
Published Version (Please cite this version)
10.3389/fonc.2019.01185
Publication Info
Langsten, KL; Kim, JH; Sarver, AL; Dewhirst, M; & Modiano, JF (2019). Comparative Approach to the Temporo-Spatial Organization of the Tumor Microenvironment. Frontiers in Oncology, 9. 10.3389/fonc.2019.01185. Retrieved from https://hdl.handle.net/10161/20610.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Dewhirst

Mark Wesley Dewhirst

Gustavo S. Montana Distinguished Professor Emeritus of Radiation Oncology
Mark W. Dewhirst, DVM, PhD is the Gustavo S. Montana Professor of Radiation Oncology and Vice Director for Basic Science in the Duke Cancer Institute. Dr. Dewhirst has research interests in tumor hypoxia, angiogenesis, hyperthermia and drug transport. He has spent 30 years studying causes of tumor hypoxia and the use of hyperthermia to treat cancer. In collaboration with Professor David Needham in the Pratt School of Engineering, he has developed a novel thermally sensitive drug carrying liposom
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