Comparative Approach to the Temporo-Spatial Organization of the Tumor Microenvironment
Abstract
© Copyright © 2019 Langsten, Kim, Sarver, Dewhirst and Modiano. The complex ecosystem
in which tumor cells reside and interact, termed the tumor microenvironment (TME),
encompasses all cells and components associated with a neoplasm that are not transformed
cells. Interactions between tumor cells and the TME are complex and fluid, with each
facet coercing the other, largely, into promoting tumor progression. While the TME
in humans is relatively well-described, a compilation and comparison of the TME in
our canine counterparts has not yet been described. As is the case in humans, dog
tumors exhibit greater heterogeneity than what is appreciated in laboratory animal
models, although the current level of knowledge on similarities and differences in
the TME between dogs and humans, and the practical implications of that information,
require further investigation. This review summarizes some of the complexities of
the human and mouse TME and interjects with what is known in the dog, relaying the
information in the context of the temporo-spatial organization of the TME. To the
authors' knowledge, the development of the TME over space and time has not been widely
discussed, and a comprehensive review of the canine TME has not been done. The specific
topics covered in this review include cellular invasion and interactions within the
TME, metabolic derangements in the TME and vascular invasion, and the involvement
of the TME in tumor spread and metastasis.
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https://hdl.handle.net/10161/20610Published Version (Please cite this version)
10.3389/fonc.2019.01185Publication Info
Langsten, KL; Kim, JH; Sarver, AL; Dewhirst, M; & Modiano, JF (2019). Comparative Approach to the Temporo-Spatial Organization of the Tumor Microenvironment.
Frontiers in Oncology, 9. 10.3389/fonc.2019.01185. Retrieved from https://hdl.handle.net/10161/20610.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Mark Wesley Dewhirst
Gustavo S. Montana Distinguished Professor Emeritus of Radiation Oncology
Mark W. Dewhirst, DVM, PhD is the Gustavo S. Montana Professor of Radiation Oncology
and Vice Director for Basic Science in the Duke Cancer Institute. Dr. Dewhirst has
research interests in tumor hypoxia, angiogenesis, hyperthermia and drug transport.
He has spent 30 years studying causes of tumor hypoxia and the use of hyperthermia
to treat cancer. In collaboration with Professor David Needham in the Pratt School
of Engineering, he has developed a novel thermally sensitive drug carrying liposom

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