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Host-Based Diagnostics for Acute Respiratory Infections.

dc.contributor.author Ross, Melissa H
dc.contributor.author Zick, Brittany L
dc.contributor.author Tsalik, Ephraim L
dc.date.accessioned 2020-11-01T14:38:06Z
dc.date.available 2020-11-01T14:38:06Z
dc.date.issued 2019-10
dc.identifier S0149-2918(19)30334-0
dc.identifier.issn 0149-2918
dc.identifier.issn 1879-114X
dc.identifier.uri https://hdl.handle.net/10161/21656
dc.description.abstract PURPOSE:The inappropriate use of antimicrobials, especially in acute respiratory infections (ARIs), is largely driven by difficulty distinguishing bacterial, viral, and noninfectious etiologies of illness. A new frontier in infectious disease diagnostics looks to the host response for disease classification. This article examines how host response-based diagnostics for ARIs are being used in clinical practice, as well as new developments in the research pipeline. METHODS:A limited search was conducted of the relevant literature, with emphasis placed on literature published in the last 5 years (2014-2019). FINDINGS:Advances are being made in all areas of host response-based diagnostics for ARIs. Specifically, there has been significant progress made in single protein biomarkers, as well as in various "omics" fields (including proteomics, metabolomics, and transcriptomics) and wearable technologies. There are many potential applications of a host response-based approach; a few key examples include the ability to discriminate bacterial and viral disease, presymptomatic diagnosis of infection, and pathogen-specific host response diagnostics, including modeling disease progression. IMPLICATIONS:As biomarker measurement technologies continue to improve, host response-based diagnostics will increasingly be translated to clinically available platforms that can generate a holistic characterization of an individual's health. This knowledge, in the hands of both patient and provider, can improve care for the individual patient and help fight rising rates of antibiotic resistance.
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartof Clinical therapeutics
dc.relation.isversionof 10.1016/j.clinthera.2019.06.007
dc.subject Humans
dc.subject Respiratory Tract Infections
dc.subject Gene Expression Profiling
dc.subject Proteomics
dc.subject Immunocompromised Host
dc.subject Biomarkers
dc.subject Wearable Electronic Devices
dc.title Host-Based Diagnostics for Acute Respiratory Infections.
dc.type Journal article
duke.contributor.id Tsalik, Ephraim L|0373391
dc.date.updated 2020-11-01T14:38:06Z
pubs.begin-page 1923
pubs.end-page 1938
pubs.issue 10
pubs.organisational-group School of Medicine
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Medicine, Infectious Diseases
pubs.organisational-group Duke
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 41
duke.contributor.orcid Tsalik, Ephraim L|0000-0002-6417-2042


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