Emerging arboviruses and implications for pediatric transplantation: A review.
Abstract
Recent years have brought a rise in newly emergent viral infections, primarily in
the form of previously known arthropod-transmitted viruses that have increased significantly
in both incidence and geographical range. Of particular note are DENV, CHIKV, and
ZIKV, which are transmitted mostly by Aedes species of mosquitoes that exhibit a wide
and increasing global distribution. Being important pathogens for the general population,
these viruses have the potential to be devastating in the international transplant
community, with graft rejection and death as possible outcomes of infection. In this
review, we discuss the current state of knowledge for these viruses as well as repercussions
of infection in the solid organ and HSCT population, with a focus, when possible,
on pediatric patients.
Type
Journal articleSubject
HumansCommunicable Diseases, Emerging
Arbovirus Infections
Postoperative Complications
Organ Transplantation
Risk Factors
Pediatrics
Child
Global Health
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https://hdl.handle.net/10161/22579Published Version (Please cite this version)
10.1111/petr.13303Publication Info
Freeman, Megan Culler; Coyne, Carolyn B; Green, Michael; Williams, John V; & Silva,
Laurie A (2019). Emerging arboviruses and implications for pediatric transplantation: A review. Pediatric transplantation, 23(1). pp. e13303. 10.1111/petr.13303. Retrieved from https://hdl.handle.net/10161/22579.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Carolyn Coyne
George Barth Geller Distinguished Professor of Immunology
We study the pathways by which microorganisms cross cellular barriers and the mechanisms
by which these barriers restrict microbial infections. Our studies primarily focus
on the epithelium that lines the gastrointestinal tract and on placental trophoblasts,
the cells that comprise a key cellular barrier of the human placenta. Our work is
highly multidisciplinary and encompasses aspects of cell biology, immunology, and
microbiology. Our long-term goals are to identify pathogen- and host-spe

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