Can psychological features predict antidepressant response to rTMS? A Discovery-Replication approach.
Abstract
<h4>Background</h4>Few studies focused on the relationship between psychological measures,
major depressive disorder (MDD) and repetitive transcranial magnetic stimulation (rTMS)
response. This study investigated several psychological measures as potential predictors
for rTMS treatment response. Additionally, this study employed two approaches to evaluate
the robustness of our findings by implementing immediate replication and full-sample
exploration with strict p-thresholding.<h4>Methods</h4>This study is an open-label,
multi-site study with a total of 196 MDD patients. The sample was subdivided in a
Discovery (60% of total sample, n = 119) and Replication sample (40% of total sample,
n = 77). Patients were treated with right low frequency (1 Hz) or left high frequency
(10 Hz) rTMS at the dorsolateral prefrontal cortex. Clinical variables [Beck Depression
Inventory (BDI), Neuroticism, Extraversion, Openness Five-Factor Inventory, and Depression,
Anxiety, and Stress Scale, and BDI subscales] were obtained at baseline, post-treatment,
and at follow-up. Predictors were analyzed in terms of statistical association, robustness
(independent replication), as well as for their clinical relevance [positive predictive
value (PPV) and negative predictive value (NPV)].<h4>Results</h4>Univariate analyses
revealed that non-responders had higher baseline anhedonia scores. Anhedonia scores
at baseline correlated negatively with total BDI percentage change over time. This
finding was replicated. However, anhedonia scores showed to be marginally predictive
of rTMS response, and neither PPV nor NPV reached the levels of clinical relevance.<h4>Conclusions</h4>This
study suggests that non-responders to rTMS treatment have higher baseline anhedonia
scores. However, anhedonia was only marginally predictive of rTMS response. Since
all other psychological measures did not show predictive value, it is concluded that
psychological measures cannot be used as clinically relevant predictors to rTMS response
in MDD.
Type
Journal articleSubject
Prefrontal CortexHumans
Treatment Outcome
Predictive Value of Tests
ROC Curve
Depressive Disorder, Major
Personality Inventory
Adult
Middle Aged
Female
Male
Transcranial Magnetic Stimulation
Depressive Disorder, Treatment-Resistant
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https://hdl.handle.net/10161/24805Published Version (Please cite this version)
10.1017/s0033291718004191Publication Info
Krepel, Noralie; Rush, A John; Iseger, Tabitha A; Sack, Alexander T; & Arns, Martijn (2020). Can psychological features predict antidepressant response to rTMS? A Discovery-Replication
approach. Psychological medicine, 50(2). pp. 264-272. 10.1017/s0033291718004191. Retrieved from https://hdl.handle.net/10161/24805.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Augustus John Rush
Adjunct Professor in the Department of Psychiatry and Behavioral Sciences

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