Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effects.
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2022-07-12
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The ultrafast spatiotemporal dynamics of large-scale neural networks can be examined using resting-state electroencephalography (EEG) microstates, representing transient periods of synchronized neural activity that evolve dynamically over time. In adults, four canonical microstates have been shown to explain most topographic variance in resting-state EEG. Their temporal structures are age-, sex- and state-dependent, and are susceptible to pathological brain states. However, no studies have assessed the spatial and temporal properties of EEG microstates exclusively during early childhood, a critical period of rapid brain development. Here we sought to investigate EEG microstates recorded with high-density EEG in a large sample of 103, 4-8-year-old children. Using data-driven k-means cluster analysis, we show that the four canonical microstates reported in adult populations already exist in early childhood. Using multiple linear regressions, we demonstrate that the temporal dynamics of two microstates are associated with age and sex. Source localization suggests that attention- and cognitive control-related networks govern the topographies of the age- and sex-dependent microstates. These novel findings provide unique insights into functional brain development in children captured with EEG microstates.
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Bagdasarov, Armen, Kenneth Roberts, Lucie Bréchet, Denis Brunet, Christoph M Michel and Michael S Gaffrey (2022). Spatiotemporal dynamics of EEG microstates in four- to eight-year-old children: Age- and sex-related effects. Developmental cognitive neuroscience, 57. p. 101134. 10.1016/j.dcn.2022.101134 Retrieved from https://hdl.handle.net/10161/25570.
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Armen Bagdasarov
Armen Bagdasarov is a fourth-year Ph.D. student in clinical psychology at Duke University. He received his B.A. in psychology at the University of Pennsylvania in 2018. Following, he completed the two-year Sara S. Sparrow Fellowship in Clinical Neuroscience at the Yale Child Study Center. In 2020, Armen received the National Science Foundation Graduate Research Fellowship.
Michael Santo Gaffrey
Michael S. Gaffrey, Ph.D. is an Assistant Professor at Duke University in the Department of Psychology & Neuroscience. He is also Director of Duke’s Early Experience and the Developing Brain (DEED) lab. He received his PhD in Clinical Psychology from the University of Wisconsin, Milwaukee and completed a postdoctoral fellowship in developmental clinical and affective neuroscience at the Washington University School of Medicine. Dr. Gaffrey has also completed advanced training in infant mental health practice and policy through the ZERO-TO-THREE Leadership Development Institute.
Dr. Gaffrey is firmly committed to studying, treating, and advocating for the health and well-being of vulnerable infants and young children. To this end, his research endeavors include the use of behavioral and neuroimaging methodologies to better understand biological pathways underlying risk and resilience to early life stress and related environmental challenges. He is also actively involved in using the tools of developmental neuroscience to better understand how preventive intervention programs targeting infants at risk for negative socioemotional outcomes, including depression and autism spectrum disorder, can be used more effectively. Through the integration of clinical practice and innovative research, Dr. Gaffrey hopes to reduce the impact of risk factors that contribute to unfavorable health outcomes for vulnerable infants and families. Furthermore, Dr. Gaffrey believes we can better foster healthy environments for growing children and ensure the well-being of all infants and families by bringing objective research and practice-based knowledge to policy and public arenas.
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