Browsing Duke Scholarly Works by Affiliation of Duke Author(s) "School of Nursing"
Now showing items 1-20 of 190
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A community-based intervention increases physical activity and reduces obesity in school-age children in North Carolina.
(Child Obes, 2015-06)BACKGROUND: Community-based interventions are promising approaches to obesity prevention, but few studies have prospectively evaluated them. The aim of this study was to evaluate a natural experiment—a community intervention ... -
A Framework for Resident Participation in Population Health.
(Academic medicine : journal of the Association of American Medical Colleges, 2018-09-25)Population health experiences have become more common in medical education. Yet, most resident population health experiences are in patient panel management and fail to connect with the rapidly growing movement of cross-sector, ... -
A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.
(Open Forum Infect Dis, 2016-01)Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores ... -
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
(PLoS One, 2013)There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted the challenges and limitations of traditional ... -
A latent factor linear mixed model for high-dimensional longitudinal data analysis.
(Statistics in medicine, 2013-10)High-dimensional longitudinal data involving latent variables such as depression and anxiety that cannot be quantified directly are often encountered in biomedical and social sciences. Multiple responses are used to characterize ... -
A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.
(Arthritis Res Ther, 2016-04-12)BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our objective was to explore the relationships of GlycA, a measure of glycosylated acute phase proteins, with inflammation and cardiometabolic ... -
A Phase II single-arm trial of palonosetron for the prevention of acute and delayed chemotherapy-induced nausea and vomiting in malignant glioma patients receiving multidose irinotecan in combination with bevacizumab.
(Ther Clin Risk Manag, 2017)PURPOSE: Given that the prognosis of recurrent malignant glioma (MG) remains poor, improving quality of life (QoL) through symptom management is important. Meta-analyses establishing antiemetic guidelines have demonstrated ... -
A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.
(PloS one, 2014-01)Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response to stress may be one of a number of biological mechanisms that links psychological stress to depressive ... -
A qualitative analysis of the Three Good Things intervention in healthcare workers.
(BMJ open, 2017-06-13)BACKGROUND:Intensive care unit (ICU) personnel have an elevated prevalence of job-related burn-out and post-traumatic stress disorder, which can ultimately impact patient care. To strengthen healthcare workers' skills to ... -
A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania.
(BMC Infect Dis, 2014-02-20)BACKGROUND: Routine tuberculosis culture remains unavailable in many high-burden areas, including Tanzania. This study sought to determine the impact of providing mycobacterial culture results over standard of care ... -
A strategy to advance the evidence base in palliative medicine: formation of a palliative care research cooperative group.
(J Palliat Med, 2010-12)BACKGROUND: Palliative medicine has made rapid progress in establishing its scientific and clinical legitimacy, yet the evidence base to support clinical practice remains deficient in both the quantity and quality of published ... -
Adherence to diabetes guidelines for screening, physical activity and medication and onset of complications and death.
(J Diabetes Complications, 2015-11)AIMS: Analyze relationships between adherence to guidelines for diabetes care - regular screening; physical activity; and medication - and diabetes complications and mortality. METHODS: Outcomes were onset of congestive ... -
Alglucosidase alfa enzyme replacement therapy as a therapeutic approach for glycogen storage disease type III.
(Mol Genet Metab, 2013-02)We investigated the feasibility of using recombinant human acid-α glucosidase (rhGAA, Alglucosidase alfa), an FDA approved therapy for Pompe disease, as a treatment approach for glycogen storage disease type III (GSD III). ... -
An integrated transcriptome and expressed variant analysis of sepsis survival and death.
(Genome Med, 2014)BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor ... -
Anti-cholinergic load, health care utilization, and survival in people with advanced cancer: a pilot study.
(J Palliat Med, 2010-06)INTRODUCTION: Anti-cholinergic medications have been associated with increased risks of cognitive impairment, premature mortality and increased risk of hospitalisation. Anti-cholinergic load associated with medication increases ... -
Antibiotic overuse for acute respiratory tract infections in Sri Lanka: a qualitative study of outpatients and their physicians.
(BMC Fam Pract, 2018-03-01)BACKGROUND: Acute respiratory tract infections (ARTIs) are a common reason for antibiotic overuse worldwide. We previously showed that over 80% of outpatients presenting to a tertiary care hospital in Sri Lanka ... -
Application of the Intervention Mapping protocol to develop Keys, a family child care home intervention to prevent early childhood obesity.
(BMC Public Health, 2015-12-10)BACKGROUND: Many families rely on child care outside the home, making these settings important influences on child development. Nearly 1.5 million children in the U.S. spend time in family child care homes (FCCHs), where ... -
Are for-profit hospital conversions harmful to patients and to Medicare?
(Rand J Econ, 2002)We examine how changes in hospital ownership to and from for-profit status affect quality and Medicare payments per hospital stay. We hypothesize that hospitals converting to for-profit ownership boost post acquisition ... -
Are mature smokers misinformed?
(J Health Econ, 2009-03)While there are many reasons to continue to smoke in spite of its consequences for health, the concern that many smoke because they misperceive the risks of smoking remains a focus of public discussion and motivates tobacco ... -
Are quit attempts among U.S. female nurses who smoke different from female smokers in the general population? An analysis of the 2006/2007 tobacco use supplement to the current population survey.
(BMC Womens Health, 2012-03-19)BACKGROUND: Smoking is a significant women's health issue. Examining smoking behaviors among occupational groups with a high prevalence of women may reveal the culture of smoking behavior and quit efforts of female smokers. ...
