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    • ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. 

      Alzheimer’s Disease Neuroimaging Initiative; Barres, BA; Baufeld, C; Boxer, AL; Butovsky, O; Cruchaga, C; Del-Aguila, JL; ... (34 authors) (Nature, 2017-09-28)
      APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE independently influences tau pathology, the other ...