Browsing Duke Scholarly Works by Subject "P-Glycoprotein"

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Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor.

Mendell, Jeanne; Zahir, Hamim; Matsushima, Nobuko; Noveck, Robert; Lee, Frank; Chen, Shuquan; Zhang, George; ... (8 authors) (Am J Cardiovasc Drugs, 2013-10)

BACKGROUND: Edoxaban, an oral direct factor Xa inhibitor, is in development for thromboprophylaxis, including prevention of stroke and systemic embolism in patients with atrial fibrillation (AF). P-glycoprotein (P-gp), an ...