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Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. 

Tachibana, Hideo; Naga Prasad, Sathyamangla V; Lefkowitz, Robert J; Koch, Walter J; Rockman, Howard A (Circulation, 2005-02-08)
BACKGROUND: Heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased level of myocardial betaAR kinase 1 (betaARK1). Our previous studies have shown that inhibition ...
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When 7 transmembrane receptors are not G protein-coupled receptors. 

Rajagopal, Keshava; Lefkowitz, Robert J; Rockman, Howard A (J Clin Invest, 2005-11)
Classically, 7 transmembrane receptors transduce extracellular signals by coupling to heterotrimeric G proteins, although recent in vitro studies have clearly demonstrated that they can also signal via G protein-independent ...
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An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. 

Ait-Azzouzene, Djemel; Verkoczy, Laurent; Peters, Jorieke; Gavin, Amanda; Skog, Patrick; Vela, José Luis; Nemazee, David (J Exp Med, 2005-03-07)
Understanding immune tolerance mechanisms is a major goal of immunology research, but mechanistic studies have generally required the use of mouse models carrying untargeted or targeted antigen receptor transgenes, which ...
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Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway. 

Ni, Jing; Wen, Xingqiao; Yao, Jorge; Chang, Hong-Chiang; Yin, Yi; Zhang, Min; Xie, Shaozhen; ... (13 authors) (Cancer research, 2005-11)
Epidemiologic studies suggested that vitamin E has a protective effect against prostate cancer. We showed here that tocopherol-associated protein (TAP), a vitamin E-binding protein, promoted vitamin E uptake and facilitated ...

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AuthorLefkowitz, Robert J (2)Rockman, Howard A (2)Ait-Azzouzene, Djemel (1)Chang, Hong-Chiang (1)Chang, Philip (1)Chen, Ming (1)di Sant'Agnese, Anthony (1)Gavin, Amanda (1)Koch, Walter J (1)Messing, Edward M (1)... View MoreDate Issued
2005 (4)
Type
Journal article (4)
SubjectAnimals (4)
Mice (4)
Cell Line, Tumor (2)Mice, Transgenic (2)Signal Transduction (2)Adenylyl Cyclases (1)Autoantigens (1)B-Lymphocytes (1)beta-Adrenergic Receptor Kinases (1)Bone Marrow Cells (1)... View MoreAffiliation of Duke Author(s)
Clinical Science Departments (4)
Duke (4)
Institutes and Centers (4)
Pathology (4)School of Medicine (4)Duke Cancer Institute (3)Medicine (3)Basic Science Departments (2)Biochemistry (2)Cell Biology (2)... View More
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