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Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.
(Circulation, 2005-02-08)
BACKGROUND: Heart failure is characterized by abnormalities in beta-adrenergic receptor
(betaAR) signaling, including increased level of myocardial betaAR kinase 1 (betaARK1).
Our previous studies have shown that inhibition ...
When 7 transmembrane receptors are not G protein-coupled receptors.
(J Clin Invest, 2005-11)
Classically, 7 transmembrane receptors transduce extracellular signals by coupling
to heterotrimeric G proteins, although recent in vitro studies have clearly demonstrated
that they can also signal via G protein-independent ...
An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system.
(J Exp Med, 2005-03-07)
Understanding immune tolerance mechanisms is a major goal of immunology research,
but mechanistic studies have generally required the use of mouse models carrying untargeted
or targeted antigen receptor transgenes, which ...
Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway.
(Cancer research, 2005-11)
Epidemiologic studies suggested that vitamin E has a protective effect against prostate
cancer. We showed here that tocopherol-associated protein (TAP), a vitamin E-binding
protein, promoted vitamin E uptake and facilitated ...