Now showing items 1-10 of 94
Molecular genetic testing and the future of clinical genomics.
(Nature reviews. Genetics, 2013-06)
Genomic technologies are reaching the point of being able to detect genetic variation in patients at high accuracy and reduced cost, offering the promise of fundamentally altering medicine. Still, although scientists and ...
The role of macrophages in hypertension and its complications.
(Pflugers Archiv : European journal of physiology, 2017-04)
Circulating monocytes and tissue macrophages play complex roles in the pathogenesis of hypertension, a highly prevalent disease associated with catastrophic cardiovascular morbidity. In the vasculature and kidney, ...
HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees.
(Journal of virology, 2018-04)
Induction of broadly cross-reactive antiviral humoral responses with the capacity to target globally diverse circulating strains is a key goal for HIV-1 immunogen design. A major gap in the field is the identification of ...
DOK2 inhibits EGFR-mutated lung adenocarcinoma.
(PloS one, 2013-01)
Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas and the importance of EGFR mutations for the initiation and maintenance of lung cancer is well established from mouse models and cancer ...
Endosome and INPP4B.
Extended-release ranolazine: critical evaluation of its use in stable angina.
(Vasc Health Risk Manag, 2011)
Coronary heart disease is the major cause of morbidity and mortality throughout the world, and is responsible for approximately one of every six deaths in the US. Angina pectoris is a clinical syndrome characterized ...
Metabolic regulation of T lymphocytes.
(Annu Rev Immunol, 2013)
T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP-generating processes, whereas ...
Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod.
(Drug Des Devel Ther, 2015)
Each year, despite optimal use of recommended acute and secondary prevention therapies, 4%-5% of patients with acute coronary syndrome (ACS) experience relapse of ACS or other cardiovascular events including stroke, heart ...
Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats.
(Brain Struct Funct, 2013-05)
Rodent models of Huntington disease (HD) are valuable tools for investigating HD pathophysiology and evaluating new therapeutic approaches. Non-invasive characterization of HD-related phenotype changes is important for monitoring ...
Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery.
(Int J Nanomedicine, 2012)
BACKGROUND: Modular nanotransporters (MNT) are recombinant multifunctional polypeptides created to exploit a cascade of cellular processes, initiated with membrane receptor recognition to deliver selective short-range and ...