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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
Implementation and randomized controlled trial evaluation of universal postnatal nurse home visiting.
(Am J Public Health, 2014-02)
OBJECTIVES: We evaluated whether a brief, universal, postnatal nurse home-visiting
intervention can be implemented with high penetration and fidelity, prevent emergency
health care services, and promote positive parenting ...
Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya.
(PLoS One, 2017)
BACKGROUND: Atrial fibrillation (AF) is a major contributor to the global cardiovascular
disease burden. The clinical profile and outcomes of AF patients with valvular heart
diseases in sub-Saharan Africa (SSA) have not ...
Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
(Hum Brain Mapp, 2014-06)
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination
and iron deposition in the brain evolve ...
The role of lipid-related genes, aging-related processes, and environment in healthspan.
(Aging Cell, 2013-04)
The inherent complexity of aging-related traits can temper progress in unraveling
the genetic origins of healthspan. We focus on two generations in the Framingham Heart
Study, the original (FHS) and offspring (FHSO) cohorts, ...
Amygdala-prefrontal cortex functional connectivity during threat-induced anxiety and goal distraction.
(Biol Psychiatry, 2015-02-15)
BACKGROUND: Anxiety produced by environmental threats can impair goal-directed processing
and is associated with a range of psychiatric disorders, particularly when aversive
events occur unpredictably. The prefrontal cortex ...
Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging.
(Am J Psychiatry, 2002-06)
OBJECTIVE: The authors sought to increase understanding of the brain mechanisms involved
in cigarette addiction by identifying neural substrates modulated by visual smoking
cues in nicotine-deprived smokers. METHOD: Event-related ...
Trade-offs between cancer and other diseases: do they exist and influence longevity?
(Rejuvenation Res, 2010-08)
Relationships between aging, disease risks, and longevity are not yet well understood.
For example, joint increases in cancer risk and total survival observed in many human
populations and some experimental aging studies ...
Comparative genomics reveals insights into avian genome evolution and adaptation.
(Science, 2014-12-12)
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance
across many research fields. We explored bird macroevolution using full genomes from
48 avian species representing all major extant clades. ...
Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.
(PLoS Genet, 2014-01)
Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven
uniqueness in humans and its prominent role in geriatrics and gerontology. We use
large samples of longitudinally followed ...