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Renal systems biology of patients with systemic inflammatory response syndrome.

Cairns, CB; Dinwiddie, DL; Fowler, Vance Garrison Jr; Glew, RH; Glickman, Seth W; Harrod, KS; Jaehne, AK; ... (21 authors) (Kidney Int, 2015-10)

A systems biology approach was used to comprehensively examine the impact of renal disease and hemodialysis (HD) on patient response during critical illness. To achieve this, we examined the metabolome, proteome, ...

Host gene expression classifiers diagnose acute respiratory illness etiology.

Burke, T; Cairns, CB; Carin, Lawrence; Fowler, Vance Garrison Jr; Freeman, DH; Ginsburg, Geoffrey Steven; Glickman, Seth W; ... (24 authors) (Sci Transl Med, 2016-01-20)

Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ...

Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.

Ahn, SH; Cairns, CB; Cyr, Derek; Fowler, Vance Garrison Jr; Ginsburg, Geoffrey Steven; Glickman, Seth W; Kingsmore, Stephen F; ... (17 authors) (PLoS One, 2013)

Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ...

Metabolomic derangements are associated with mortality in critically ill adult patients.

Baron, RM; Choi, AM; Fowler, Vance Garrison Jr; Fredenburgh, LE; Gazourian, L; Haspel, JA; Hunninghake, GM; ... (17 authors) (PLoS One, 2014)

OBJECTIVE: To identify metabolomic biomarkers predictive of Intensive Care Unit (ICU) mortality in adults. RATIONALE: Comprehensive metabolomic profiling of plasma at ICU admission to identify biomarkers associated with ...

A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.

Carin, Lawrence; Chen, M; Gilbert, AG; Ginsburg, Geoffrey Steven; Glickman, Seth W; Hero, Alfred; Huang, Y; ... (17 authors) (PLoS One, 2013)

There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted the challenges and limitations of traditional ...

Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.

Carin, Lawrence; Dobigeon, N; Ginsburg, Geoffrey Steven; Hero, Alfred; Huang, Y; Kingsmore, Stephen F; McClain, MT; ... (15 authors) (PLoS Genet, 2011-08)

Exposure to influenza viruses is necessary, but not sufficient, for healthy human hosts to develop symptomatic illness. The host response is an important determinant of disease progression. In order to delineate host molecular ...