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    Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations. 

    Wei, Qingyi; Zhu, Jinhong; Wang, Mengyun; Zhu, Meiling; He, Jin; Wang, Jiu-Cun; Jin, Li; ... (9 authors) (Scientific reports, 2015-01)
    Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway may contribute to carcinogenesis. We genotyped five potentially functional PIK3R1 and mTOR SNPs in 1116 esophageal squamous cell cancer (ESCC) ...
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    Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival. 

    Liu, Zhensheng; Wei, Qingyi; Yin, Jieyun; Liu, Hongliang; Wang, Li-E; Chen, Wei V; Zhu, Dakai; ... (10 authors) (The Journal of investigative dermatology, 2015-02)
    Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using data derived from published genome-wide association ...
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    Steps to Health employee weight management randomized control trial: short-term follow-up results. 

    Brouwer, Rebecca; Dement, John M; Eisenstein, EL; Fuemmeler, Bernard F; Gulley, L; Joyner, J; Østbye, Truls; ... (9 authors) (J Occup Environ Med, 2015-02)
    OBJECTIVE: To present the short-term follow-up findings of the Steps to Health study, a randomized trial to evaluate the effectiveness of two employee weight management programs offered within Duke University and the Health ...
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    Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci. 

    Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team; Ji, Y; Kertai, Miklos David; Kraus, William Erle; Li, YJ; Li, YW; Mathew, Joseph P; ... (13 authors) (Kidney Int, 2015-10)
    Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following ...
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    Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction. 

    Cyr, Derek; Ginsburg, Geoffrey Steven; Kraus, William Erle; Lucas, Joseph E; Newby, Laura Kristin; Rose, Jason J; Voora, Deepak; ... (9 authors) (PLoS One, 2015)
    BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting that respiratory viral infection may induce biologic pathways that contribute to MI. We tested the hypotheses that 1) a validated ...
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    Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study. 

    Becker, RC; Boyle, SH; Harrison, Robert W; Jiang, Wei; Kuhn, C; O'Connor, Christopher Michael; Ortel, TL; ... (11 authors) (Am Heart J, 2015-04)
    BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is common in patients with ischemic heart disease (IHD) and associated with a poorer cardiovascular prognosis. Platelet hyperactivity is an important factor in ...
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    Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery. 

    Alexander, John Hunter Peel; Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team; Ji, Y; Joseph, D; Kertai, Miklos David; Li, YJ; Li, YW; ... (11 authors) (BMJ Open, 2015-05-06)
    OBJECTIVES: Identification of patient subpopulations susceptible to develop myocardial infarction (MI) or, conversely, those displaying either intrinsic cardioprotective phenotypes or highly responsive to protective interventions ...
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    Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni. 

    Andrade, ZA; Chan, IS; Choi, SS; Diehl, Anna Mae; Lambertucci, JR; Machado, MV; Otoni, A; ... (19 authors) (Clin Sci (Lond), 2015-11)
    Schistosomiasis is a major cause of portal hypertension worldwide. It associates with portal fibrosis that develops during chronic infection. The mechanisms by which the pathogen evokes these host responses remain unclear. ...
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    Renal systems biology of patients with systemic inflammatory response syndrome. 

    Cairns, CB; Dinwiddie, DL; Fowler, Vance Garrison Jr; Glew, RH; Glickman, Seth W; Harrod, KS; Jaehne, AK; ... (21 authors) (Kidney Int, 2015-10)
    A systems biology approach was used to comprehensively examine the impact of renal disease and hemodialysis (HD) on patient response during critical illness. To achieve this, we examined the metabolome, proteome, ...
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    Nurse-led behavioral management of diabetes and hypertension in community practices: a randomized trial. 

    Bosworth, Hayden Barry; Coffman, CJ; Dolor, RJ; Edelman, David Edward; Granger, BB; Harris, AJ; Lindquist, JH; ... (9 authors) (J Gen Intern Med, 2015-05)
    BACKGROUND: Several trials have demonstrated the efficacy of nurse telephone case management for diabetes (DM) and hypertension (HTN) in academic or vertically integrated systems. Little is known about the real-world potency ...
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    AuthorWei, Qingyi (4)Anstrom, Kevin J (3)DeVore, Adam David (3)Fowler, Vance Garrison Jr (3)Mentz, Robert John (3)AbouEzzeddine, OF (2)Bart, BA (2)Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team (2)Eisenstein, EL (2)Felker, G Michael (2)... View MoreDate Issued
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