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Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans.

Bidlingmaier, M; Cummings, DE; D'Alessio, David A; Davis, HW; Kahn, SE; Prigeon, RL; Tong, Jenny; ... (8 authors) (Diabetes, 2010-09)

OBJECTIVE: The orexigenic gut hormone ghrelin and its receptor are present in pancreatic islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin secretion in humans has not been established. ...

Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection.

Corey, GR; Wilcox, M; Talbot, GH; Friedland, HD; Baculik, T; Witherell, GW; Critchley, I; ... (9 authors) (Clin Infect Dis, 2010-09-15)

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of complicated skin and skin-structure infection (cSSSI). Increasing antimicrobial resistance in cSSSI has led to a need for new safe and effective ...

Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA.

Benoit, SR; Engel, J; Evans, Sharon E; Frederick, J; Kutty, PK; McDonald, LC; Naggie, Susanna; ... (9 authors) (Emerg Infect Dis, 2010-02)

We determined estimated incidence of and risk factors for community-associated Clostridium difficile infection (CA-CDI) among patients treated at 6 North Carolina hospitals. CA-CDI case-patients were defined as adults (>18 ...

Can metaphors and analogies improve communication with seriously ill patients?

Alexander, SC; Arnold, RM; Casarett, D; Fishman, JM; Pickard, A; Pollak, Kathryn IIonka; Tulsky, JA (J Palliat Med, 2010-03)

OBJECTIVE: It is not known how often physicians use metaphors and analogies, or whether they improve patients' perceptions of their physicians' ability to communicate effectively. Therefore, the objective of this study was ...

Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254).

Catterall, JB; Flannery, CR; Kraus, Virginia Byers; Stabler, Thomas (Arthritis Res Ther, 2010)

INTRODUCTION: Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In this study, to better understand ...

Variation in the type and frequency of postoperative invasive Staphylococcus aureus infections according to type of surgical procedure.

Anderson, DJ; Arduino, JM; Choi, YI; Fowler, Vance Garrison Jr; Friedman, JY; Grussemeyer, CA; Hardy, C; ... (11 authors) (Infect Control Hosp Epidemiol, 2010-07)

OBJECTIVE: To determine the epidemiological characteristics of postoperative invasive Staphylococcus aureus infection following 4 types of major surgical procedures.design. Retrospective cohort study. SETTING: Eleven hospitals ...

Pairing QuantiFERON gold in-tube with opt-out HIV testing in a tuberculosis contact investigation in the Southeastern United States.

Baker, AV; Bissette, Deborah J; Chen, L; Cox, GM; Erlandson, K; Gadkowski, LB; Goswami, ND; ... (12 authors) (AIDS Patient Care STDS, 2010-09)

Knowing one's HIV status is particularly important in the setting of recent tuberculosis (TB) exposure. Blood tests for assessment of tuberculosis infection, such as the QuantiFERON Gold in-tube test (QFT; Cellestis Limited, ...

Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.

AIDS Vaccine Evaluation Group; Berger, D; Duerr, A; Eldridge, J; Fast, P; Ferarri, G; Ginsberg, R; ... (17 authors) (PLoS One, 2010-08-10)

BACKGROUND: A peptide vaccine was produced containing B and T cell epitopes from the V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The peptide mixture was formulated as an emulsion in incomplete ...