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Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials.
(J Immunol Methods, 2014-07)
A large repository of cryopreserved peripheral blood mononuclear cells (PBMCs) samples
was created to provide laboratories testing the specimens from human immunodeficiency
virus-1 (HIV-1) vaccine clinical trials the material ...
Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
(Hum Brain Mapp, 2014-06)
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination
and iron deposition in the brain evolve ...
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...
Institutional review boards' use and understanding of certificates of confidentiality.
(PloS one, 2012-01)
Certificates of Confidentiality, issued by agencies of the U.S. government, are regarded
as an important tool for meeting ethical and legal obligations to safeguard research
participants' privacy and confidentiality. By ...
Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates.
(Diseases of the esophagus : official journal of the International Society for Diseases
of the Esophagus, 2018-05)
Gastroesophageal reflux disease and esophageal dysmotility are prevalent in patients
with advanced lung disease and are associated with graft dysfunction following lung
transplantation. As a result, many transplant centers ...
Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.
(Ann Am Thorac Soc, 2016-03)
RATIONALE: Limitations in methods for the rapid diagnosis of hospital-acquired infections
often delay initiation of effective antimicrobial therapy. New diagnostic approaches
offer potential clinical and cost-related improvements ...
Polymorphisms in Fibronectin Binding Proteins A and B among Staphylococcus aureus Bloodstream Isolates Are Not Associated with Arthroplasty Infection.
(PLoS One, 2015)
BACKGROUND: Nonsynonymous single nucleotide polymorphisms (SNPs) in fibronectin binding
protein A (fnbA) of Staphylococcus aureus are associated with cardiac device infections.
However, the role of fnbA SNPs in S. aureus ...
Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.
(Scientific reports, 2015-01)
Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway
may contribute to carcinogenesis. We genotyped five potentially functional PIK3R1
and mTOR SNPs in 1116 esophageal squamous cell cancer (ESCC) ...
Steps to Health employee weight management randomized control trial: short-term follow-up results.
(J Occup Environ Med, 2015-02)
OBJECTIVE: To present the short-term follow-up findings of the Steps to Health study,
a randomized trial to evaluate the effectiveness of two employee weight management
programs offered within Duke University and the Health ...
Nurse-led behavioral management of diabetes and hypertension in community practices: a randomized trial.
(J Gen Intern Med, 2015-05)
BACKGROUND: Several trials have demonstrated the efficacy of nurse telephone case
management for diabetes (DM) and hypertension (HTN) in academic or vertically integrated
systems. Little is known about the real-world potency ...