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    Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. 

    Glower, Donald D Jr; Hata, Jonathan Andrew; Koch, Walter J; Lefkowitz, Robert J; Shah, AS; White, DC (Proc Natl Acad Sci U S A, 2000-05-09)
    When the heart fails, there is often a constellation of biochemical alterations of the beta-adrenergic receptor (betaAR) signaling system, leading to the loss of cardiac inotropic reserve. betaAR down-regulation and functional ...
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    Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. 

    Glower, Donald D Jr; Hata, Jonathan Andrew; Koch, Walter J; Kypson, Alan P; Lefkowitz, Robert J; Lilly, R Eric; Pippen, Anne; ... (10 authors) (Circulation, 2000-02-01)
    BACKGROUND: Genetic modulation of ventricular function may offer a novel therapeutic strategy for patients with congestive heart failure. Myocardial overexpression of beta(2)-adrenergic receptors (beta(2)ARs) has been shown ...
     

     

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    Author
    Glower, Donald D Jr (2)
    Hata, Jonathan Andrew (2)Koch, Walter J (2)
    Lefkowitz, Robert J (2)
    Shah, AS (2)Kypson, Alan P (1)Lilly, R Eric (1)Pippen, Anne (1)Silvestry, Scott Christopher (1)Tai, Oliver (1)... View MoreDate Issued2000 (2)TypeJournal article (2)Subject
    Adenoviridae (2)
    Animals (2)Genetic Therapy (2)Genetic Vectors (2)Heart Rate (2)
    Humans (2)
    Male (2)Myocardium (2)Rabbits (2)Ventricular Function, Left (2)... View MoreAffiliation of Duke Author(s)Basic Science Departments (2)Biochemistry (2)
    Chemistry (2)
    Clinical Science Departments (2)Duke (2)Duke Cancer Institute (2)Institutes and Centers (2)Medicine (2)Medicine, Cardiology (2)Pathology (2)... View More