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Renal systems biology of patients with systemic inflammatory response syndrome.
(Kidney Int, 2015-10)
A systems biology approach was used to comprehensively examine the impact of renal
disease and hemodialysis (HD) on patient response during critical illness. To achieve
this, we examined the metabolome, proteome, ...
Host gene expression classifiers diagnose acute respiratory illness etiology.
(Sci Transl Med, 2016-01-20)
Acute respiratory infections caused by bacterial or viral pathogens are among the
most common reasons for seeking medical care. Despite improvements in pathogen-based
diagnostics, most patients receive inappropriate antibiotics. ...
Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.
(Ann Am Thorac Soc, 2016-03)
RATIONALE: Limitations in methods for the rapid diagnosis of hospital-acquired infections
often delay initiation of effective antimicrobial therapy. New diagnostic approaches
offer potential clinical and cost-related improvements ...
Metabolomic derangements are associated with mortality in critically ill adult patients.
(PLoS One, 2014)
OBJECTIVE: To identify metabolomic biomarkers predictive of Intensive Care Unit (ICU)
mortality in adults. RATIONALE: Comprehensive metabolomic profiling of plasma at ICU
admission to identify biomarkers associated with ...