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Safety and efficacy of ledipasvir-sofosbuvir in black patients with hepatitis C virus infection: A retrospective analysis of phase 3 data.
(Hepatology, 2016-02)
UNLABELLED: Black patients chronically infected with genotype 1 hepatitis C virus
(HCV) have historically had lower rates of response to interferon-based treatment
than patients of other races. In the phase 3 ION program, ...
Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.
(Ann Am Thorac Soc, 2016-03)
RATIONALE: Limitations in methods for the rapid diagnosis of hospital-acquired infections
often delay initiation of effective antimicrobial therapy. New diagnostic approaches
offer potential clinical and cost-related improvements ...
Nonmedical Opioid Pain Relievers and All-Cause Mortality: A 27-Year Follow-Up From the Epidemiologic Catchment Area Study.
(American journal of public health, 2016-03)
We investigated whether nonmedical opioid pain reliever use is associated with higher
mortality in the general US population.We assessed the history of nonmedical opioid
pain reliever use among 9985 people interviewed at ...
Interrogation of individual intratumoral B lymphocytes from lung cancer patients for molecular target discovery.
(Cancer Immunol Immunother, 2016-02)
Intratumoral B lymphocytes are an integral part of the lung tumor microenvironment.
Interrogation of the antibodies they express may improve our understanding of the
host response to cancer and could be useful in elucidating ...
A Randomized Phase II Crossover Study of Imatinib or Rituximab for Cutaneous Sclerosis after Hematopoietic Cell Transplantation.
(Clin Cancer Res, 2016-01-15)
PURPOSE: Cutaneous sclerosis occurs in 20% of patients with chronic graft-versus-host
disease (GVHD) and can compromise mobility and quality of life. EXPERIMENTAL DESIGN:
We conducted a prospective, multicenter, randomized, ...
Pre-miRNA variants as predictors of clinical outcome in patients with squamous cell carcinomas of the nonoropharynx.
(Oncotarget, 2016-05)
Functional polymorphisms of miRNAs may affect the function and target expression of
miRNAs, which can, in turn, affect the biological activity, etiology, and prognosis
of cancer. We hypothesized that four common polymorphisms ...
Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.
(Oncotarget, 2016-05)
The interleukin-6 (IL-6)/JAK/STAT3 signaling pathway plays a central role in inflammation-mediated
cancers, including gastric cancer (GCa). We evaluated associations between 10 potentially
functional single nucleotide ...
A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.
(Arthritis Res Ther, 2016-04-12)
BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our
objective was to explore the relationships of GlycA, a measure of glycosylated acute
phase proteins, with inflammation and cardiometabolic ...
The Association of Gasoline Prices With Hospital Utilization and Costs for Motorcycle and Nonmotorcycle Motor Vehicle Injuries in the United States.
(Medical care, 2016-09)
This study examined the association between gasoline prices and hospitalizations for
motorcycle and nonmotorcycle motor vehicle crash (MVC) injuries.Data on inpatient
hospitalizations were obtained from the 2001 to 2010 ...
Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy.
(Oncotarget, 2016-06)
Common single nucleotide polymorphisms (SNPs) in miRNAs may affect miRNA functions
and their target expression and thus may affect biological activities and cancer etiology
as well as prognosis. Thus, we determined whether ...