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Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.

Kohout, TA; Lefkowitz, Robert J; Mao, L; McDonald, Patricia H; Perry, SJ; Rockman, Howard A; Takaoka, H (Circulation, 2001-11-13)

BACKGROUND: Stimulation of beta(1)- and beta(2)-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the beta(3)AR is also expressed in the human heart and that its ...