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    Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. 

    Kohout, TA; Lefkowitz, Robert J; Mao, L; McDonald, Patricia H; Perry, SJ; Rockman, Howard A; Takaoka, H (Circulation, 2001-11-13)
    BACKGROUND: Stimulation of beta(1)- and beta(2)-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the beta(3)AR is also expressed in the human heart and that its ...
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    Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. 

    Barki-Harrington, L; Chen, J; Le Corvoisier, P; Lefkowitz, Robert J; Lemaire, A; Naga Prasad, SV; Noma, T; ... (11 authors) (J Clin Invest, 2007-09)
    Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors (betaARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl ...
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    Catecholamines, cardiac beta-adrenergic receptors, and heart failure. 

    Koch, Walter J; Lefkowitz, Robert J; Rockman, Howard A (Circulation, 2000-04-11)
     

     

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    AuthorLefkowitz, Robert J (3)
    Rockman, Howard A (3)
    Barki-Harrington, L (1)Chen, J (1)Koch, Walter J (1)Kohout, TA (1)Le Corvoisier, P (1)Lemaire, A (1)Mao, L (1)McDonald, Patricia H (1)... View MoreDate Issued2000 (1)2001 (1)2007 (1)Type
    Journal article (3)
    SubjectAnimals (3)
    Humans (3)
    Myocardium (3)Mice (2)Mice, Transgenic (2)Signal Transduction (2)Adenylyl Cyclases (1)Adrenergic beta-Agonists (1)Arrestins (1)beta-Arrestins (1)... View MoreAffiliation of Duke Author(s)Basic Science Departments (3)Biochemistry (3)Cell Biology (3)Chemistry (3)
    Clinical Science Departments (3)
    Duke (3)Duke Cancer Institute (3)Institutes and Centers (3)
    Medicine (3)
    Medicine, Cardiology (3)... View More