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Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
(PLoS One, 2013)
Temozolomide (TMZ) is an alkylating agent shown to prolong survival in patients with
high grade glioma and is routinely used to treat melanoma brain metastases. A prominent
side effect of TMZ is induction of profound lymphopenia, ...
Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage.
(J Neuroinflammation, 2013-08-20)
BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized
by a prominent neuroinflammatory response. Antagonism of pro-inflammatory cytokines
by specific antibodies represents a compelling ...