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An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer.

Acharya, CR; Anders, CK; Anguiano, A; Barry, WT; Dressman, HK; Garman, Katherine S; Marcom, Kelly; ... (14 authors) (PLoS One, 2008-04-02)

BACKGROUND: A major challenge in oncology is the selection of the most effective chemotherapeutic agents for individual patients, while the administration of ineffective chemotherapy increases mortality and decreases quality ...

Age-specific differences in oncogenic pathway deregulation seen in human breast tumors.

Acharya, CR; Anders, CK; Blackwell, KL; Broadwater, Gloria; Foekens, JA; Garman, Katherine S; Hsu, DS; ... (14 authors) (PLoS One, 2008-01-02)

PURPOSE: To define the biology driving the aggressive nature of breast cancer arising in young women. EXPERIMENTAL DESIGN: Among 784 patients with early stage breast cancer, using prospectively-defined, age-specific cohorts ...