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    Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction. 

    Cyr, Derek; Ginsburg, Geoffrey Steven; Kraus, William Erle; Lucas, Joseph E; Newby, Laura Kristin; Rose, Jason J; Voora, Deepak; ... (9 authors) (PLoS One, 2015)
    BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting that respiratory viral infection may induce biologic pathways that contribute to MI. We tested the hypotheses that 1) a validated ...
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    Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. 

    Connelly, Jessica J; Crosslin, DR; Crossman, DC; Freedman, NJ; Ginsburg, Geoffrey Steven; Goldschmidt-Clermont, PJ; Granger, CB; ... (22 authors) (PLoS Genet, 2009-01)
    Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up genetic, biostatistical, ...
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    Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery. 

    Akushevich, Igor; Cardiothoracic Anesthesia Research Endeavors (CARE) Group; Esper, S; Fontes, Manuel Lopes; Ginsburg, Geoffrey Steven; Grichnik, Katherine Parker; Kertai, Miklos David; ... (13 authors) (J Thorac Cardiovasc Surg, 2014-04)
    OBJECTIVE: Recently, the role of β-blockers (BBs) in reducing perioperative mortality has been challenged. The conflicting results might have resulted from the extent of BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. ...
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    Host gene expression classifiers diagnose acute respiratory illness etiology. 

    Burke, T; Cairns, CB; Carin, Lawrence; Fowler, Vance Garrison Jr; Freeman, DH; Ginsburg, Geoffrey Steven; Glickman, Seth W; ... (24 authors) (Sci Transl Med, 2016-01-20)
    Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ...
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    Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans. 

    Burke, T; Chakraborty, S; Ginsburg, Geoffrey Steven; Harro, CD; McClain, MT; Nicholson, BP; Sack, DA; ... (11 authors) (J Infect Dis, 2016-05-01)
    BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is a globally prevalent cause of diarrhea. Though usually self-limited, it can be severe and debilitating. Little is known about the host transcriptional response to infection. ...
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    Protocol for implementation of family health history collection and decision support into primary care using a computerized family health history system. 

    Orlando, Lori Ann; Hauser, Elizabeth Rebecca; Christianson, C; Powell, KP; Buchanan, AH; Chesnut, Blair; Agbaje, AB; ... (9 authors) (BMC Health Serv Res, 2011-10-11)
    BACKGROUND: The CDC's Family History Public Health Initiative encourages adoption and increase awareness of family health history. To meet these goals and develop a personalized medicine implementation science research agenda, ...
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    Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 

    Ahn, SH; Cairns, CB; Cyr, Derek; Fowler, Vance Garrison Jr; Ginsburg, Geoffrey Steven; Glickman, Seth W; Kingsmore, Stephen F; ... (17 authors) (PLoS One, 2013)
    Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ...
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    Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study. 

    Barrett-Connor, E; Chiba-Falek, O; Ginsburg, Geoffrey Steven; Guyton, John Richard; McCarthy, Jeanette Joan; Nichols, M; Suchindran, Sunil (BMC Med Genet, 2010-01-19)
    BACKGROUND: Several studies have noted that genetic variants of SCARB1, a lipoprotein receptor involved in reverse cholesterol transport, are associated with serum lipid levels in a sex-dependent fashion. However, the mechanism ...
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    Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients. 

    Chu, Vivian Hou; Fowler, Vance Garrison Jr; Ginsburg, Geoffrey Steven; Glickman, Seth W; Himmel, T; Hudson, LL; Katz, JN; ... (14 authors) (Ann Am Thorac Soc, 2016-03)
    RATIONALE: Limitations in methods for the rapid diagnosis of hospital-acquired infections often delay initiation of effective antimicrobial therapy. New diagnostic approaches offer potential clinical and cost-related improvements ...
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    Effect of genetic testing for risk of type 2 diabetes mellitus on health behaviors and outcomes: study rationale, development and design. 

    Cho, Alex Han; Gallagher, Patrick; Ginsburg, Geoffrey Steven; Haga, Susanne B; Joy, Scott Victor; Kawamoto, Kensaku; Killeya-Jones, LA; ... (10 authors) (BMC Health Serv Res, 2012-01-18)
    BACKGROUND: Type 2 diabetes is a prevalent chronic condition globally that results in extensive morbidity, decreased quality of life, and increased health services utilization. Lifestyle changes can prevent the development ...
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