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Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). 

Catterall, Jonathan B; Stabler, Thomas V; Flannery, Carl R; Kraus, Virginia B (Arthritis Res Ther, 2010)
INTRODUCTION: Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In this study, to better understand ...
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Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations. 

Attur, Mukundan; Wang, Hwa-Ying; Kraus, Virginia Byers; Bukowski, Jack F; Aziz, Nazneen; Krasnokutsky, Svetlana; Samuels, Jonathan; ... (11 authors) (Ann Rheum Dis, 2010-05)
BACKGROUND: A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. OBJECTIVE: To determine whether inflammatory genetic markers could stratify ...
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Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional study. 

Emmett, Susan D; Cunningham, Coleen K; Mmbaga, Blandina T; Kinabo, Grace D; Schimana, Werner; Swai, Mark E; Bartlett, John A; ... (9 authors) (J Acquir Immune Defic Syndr, 2010-08)
BACKGROUND: Many HIV care and treatment programs in resource-limited settings rely on clinical and immunologic monitoring of antiretroviral therapy (ART), but accuracy of this strategy to detect virologic failure (VF) among ...
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Rationale and design of the Exercise Intensity Trial (EXCITE): A randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer. 

Jones, Lee W; Douglas, Pamela S; Eves, Neil D; Marcom, P Kelly; Kraus, William E; Herndon, James E; Inman, Brant A; ... (9 authors) (BMC Cancer, 2010-10-06)
BACKGROUND: The Exercise Intensity Trial (EXcITe) is a randomized trial to compare the efficacy of supervised moderate-intensity aerobic training to moderate to high-intensity aerobic training, relative to attention control, ...
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Cryptococcal cell morphology affects host cell interactions and pathogenicity. 

Okagaki, Laura H; Strain, Anna K; Nielsen, Judith N; Charlier, Caroline; Baltes, Nicholas J; Chrétien, Fabrice; Heitman, Joseph; ... (9 authors) (PLoS Pathog, 2010-06-17)
Cryptococcus neoformans is a common life-threatening human fungal pathogen. The size of cryptococcal cells is typically 5 to 10 microm. Cell enlargement was observed in vivo, producing cells up to 100 microm. These morphological ...
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Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States. 

Byrnes 3rd, EJ; Li, W; Lewit, Y; Ma, H; Voelz, K; Ren, P; Carter, DA; ... (11 authors) (PLoS Pathog, 2010-04-22)
Cryptococcus gattii causes life-threatening disease in otherwise healthy hosts and to a lesser extent in immunocompromised hosts. The highest incidence for this disease is on Vancouver Island, Canada, where an outbreak is ...
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Similar T-cell immune responses induced by group M consensus env immunogens with wild-type or minimum consensus variable regions. 

Weaver, EA; Camacho, ZT; Gao, F (AIDS Res Hum Retroviruses, 2010-05)
Consensus HIV-1 genes can decrease the genetic distances between candidate immunogens and field virus strains. To ensure the functionality and optimal presentation of immunologic epitopes, we generated two group-M consensus ...

Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. 

Meadows, Sarah K; Dressman, Holly K; Daher, Pamela; Himburg, Heather; Russell, J Lauren; Doan, Phuong; Chao, Nelson J; ... (10 authors) (PLoS One, 2010-07-12)
In the event of a terrorist-mediated attack in the United States using radiological or improvised nuclear weapons, it is expected that hundreds of thousands of people could be exposed to life-threatening levels of ionizing ...
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Implantation of mouse embryonic stem cell-derived cardiac progenitor cells preserves function of infarcted murine hearts. 

Christoforou, Nicolas; Oskouei, Behzad N; Esteso, Paul; Hill, Christine M; Zimmet, Jeffrey M; Bian, Weining; Bursac, Nenad; ... (10 authors) (PLoS One, 2010-07-12)
Stem cell transplantation holds great promise for the treatment of myocardial infarction injury. We recently described the embryonic stem cell-derived cardiac progenitor cells (CPCs) capable of differentiating into ...
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Identification of microRNAs expressed in two mosquito vectors, Aedes albopictus and Culex quinquefasciatus. 

Skalsky, Rebecca L; Vanlandingham, Dana L; Scholle, Frank; Higgs, Stephen; Cullen, Bryan R (BMC Genomics, 2010-02-18)
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression in a variety of organisms, including insects, vertebrates, and plants. miRNAs play important roles in cell development ...
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AuthorAbernethy, Amy (3)Blazer, Dan G (3)Blumenthal, James A (3)Kraus, William E (3)Wu, Li-Tzy (3)Babyak, Michael A (2)Currow, David (2)Douglas, Pamela S (2)Eves, Neil D (2)Ginsburg, Geoffrey S (2)... View MoreDate Issued
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