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Now showing items 21-30 of 88
Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery.
(BMJ Open, 2015-05-06)
OBJECTIVES: Identification of patient subpopulations susceptible to develop myocardial
infarction (MI) or, conversely, those displaying either intrinsic cardioprotective
phenotypes or highly responsive to protective interventions ...
Contemporary trends and predictors of postacute service use and routine discharge home after stroke.
(J Am Heart Assoc, 2015-02-23)
BACKGROUND: Returning home after the hospital is a primary aim for healthcare; however,
additional postacute care (PAC) services are sometimes necessary for returning stroke
patients to their pre-event status. Recent trends ...
The effect of gemfibrozil, niacin and cholestyramine combination therapy on metabolic syndrome in the Armed Forces Regression Study.
(Am J Med Sci, 2011-05)
INTRODUCTION: Metabolic syndrome is a powerful predictor of cardiovascular events
independent of overt diabetes. Dietary restriction and weight loss modify metabolic
syndrome components. This study addresses whether combination ...
Evolutionary Divergence of Gene and Protein Expression in the Brains of Humans and Chimpanzees.
(Genome Biol Evol, 2015-07-10)
Although transcriptomic profiling has become the standard approach for exploring molecular
differences in the primate brain, very little is known about how the expression levels
of gene transcripts relate to downstream protein ...
Impact of increases in high-density lipoprotein cholesterol on cardiovascular outcomes during the armed forces regression study.
(J Cardiovasc Pharmacol Ther, 2010-12)
INTRODUCTION: high-density lipoprotein (HDL) cholesterol is a well-established inverse
risk factor for cardiovascular disease. The extent to which cardiovascular risk can
be modified through changes in HDL, however, is less ...
Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.
(PLoS One, 2013)
Given the importance of cardiovascular disease (CVD) to public health and the demonstrated
heritability of both disease status and its related risk factors, identifying the
genetic variation underlying these susceptibilities ...
Benefit of Ezetimibe Added to Simvastatin in Reduced Kidney Function.
(J Am Soc Nephrol, 2017-10)
Efficacy of statin-based therapies in reducing cardiovascular mortality in individuals
with CKD seems to diminish as eGFR declines. The strongest evidence supporting the
cardiovascular benefit of statins in individuals with ...
Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya.
(PLoS One, 2017)
BACKGROUND: Atrial fibrillation (AF) is a major contributor to the global cardiovascular
disease burden. The clinical profile and outcomes of AF patients with valvular heart
diseases in sub-Saharan Africa (SSA) have not ...
Host gene expression classifiers diagnose acute respiratory illness etiology.
(Sci Transl Med, 2016-01-20)
Acute respiratory infections caused by bacterial or viral pathogens are among the
most common reasons for seeking medical care. Despite improvements in pathogen-based
diagnostics, most patients receive inappropriate antibiotics. ...
Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans.
(J Infect Dis, 2016-05-01)
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is a globally prevalent cause
of diarrhea. Though usually self-limited, it can be severe and debilitating. Little
is known about the host transcriptional response to infection. ...