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Now showing items 1-10 of 11

A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania.

Bartlett, John A; Chow, S-C; Crump, John Andrew; Cunningham, Coleen; Hamilton, Carol; Kibiki, Gibson S; Lancaster, KE; ... (18 authors) (BMC Infect Dis, 2014-02-20)

BACKGROUND: Routine tuberculosis culture remains unavailable in many high-burden areas, including Tanzania. This study sought to determine the impact of providing mycobacterial culture results over standard of care ...

Initiation of antiretroviral therapy in HIV-infected adults with skin complaints in northern Tanzania.

Bartlett, John A; Crump, John Andrew; Grossmann, H; Masenga, EJ; Mavura, DR; Minja, E (Int J Dermatol, 2015-01)

Abnormal skin findings are identified in over 90% of human immunodeficiency virus (HIV)-infected persons globally. A prospective cohort study of HIV-infected patients with skin complaints commencing antiretroviral therapy ...

Lopinavir/Ritonavir Monotherapy as Second-line Antiretroviral Treatment in Resource-Limited Settings: Week 104 Analysis of AIDS Clinical Trials Group (ACTG) A5230.

Aga, E; Badal-Faesen, S; Bartlett, John A; Crump, John Andrew; Hosseinipour, MC; Katzenstein, DA; Klingman, KL; ... (13 authors) (Clin Infect Dis, 2015-05-15)

BACKGROUND: The AIDS Clinical Trials Group (ACTG) A5230 study evaluated lopinavir/ritonavir (LPV/r) monotherapy following virologic failure (VF) on first-line human immunodeficiency virus (HIV) regimens in Africa and Asia. ...

Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort study.

Bartlett, John A; Chow, S-C; Crump, John Andrew; Maro, Venance P; Morrissey, AB; Mushi, GS; Mwako, MS; ... (12 authors) (Clin Infect Dis, 2012-07)

BACKGROUND: Disseminated tuberculosis is a major health problem in countries where generalized human immunodeficiency virus (HIV) infection epidemics coincide with high tuberculosis incidence rates; data are limited on patient ...

Brucellosis among hospitalized febrile patients in northern Tanzania.

Afwamba, IA; Bartlett, John A; Biggs, HM; Bouley, AJ; Cleaveland, S; Crump, John Andrew; Kinabo, GD; ... (11 authors) (Am J Trop Med Hyg, 2012-12)

Acute and convalescent serum samples were collected from febrile inpatients identified at two hospitals in Moshi, Tanzania. Confirmed brucellosis was defined as a positive blood culture or a ≥ 4-fold increase in ...

Lopinavir/ritonavir monotherapy after virologic failure of first-line antiretroviral therapy in resource-limited settings.

Aga, E; Badal-Faesen, S; Bartlett, John A; Crump, John Andrew; Hosseinipour, MC; Kallungal, BA; Katzenstein, DA; ... (14 authors) (AIDS, 2012-07-17)

OBJECTIVE: To evaluate virologic response rates of lopinavir/ritonavir (LPV/r) monotherapy as second-line antiretroviral treatment (ART) among adults in resource-limited settings (RLSs). DESIGN: An open-label pilot study ...

Leptospirosis among hospitalized febrile patients in northern Tanzania.

Bartlett, John A; Biggs, HM; Bui, DM; Crump, John Andrew; Galloway, RL; Kinabo, GD; Maro, Venance P; ... (12 authors) (Am J Trop Med Hyg, 2011-08)

We enrolled consecutive febrile admissions to two hospitals in Moshi, Tanzania. Confirmed leptospirosis was defined as a ≥ 4-fold increase in microscopic agglutination test (MAT) titer; probable leptospirosis as reciprocal ...

Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replication.

Cohen, MS; Crump, John Andrew; Cunningham, Coleen; Denny, Thomas Norton; Ding, Haitao; Ferrari, Guido; Freel, SA; ... (16 authors) (J Virol, 2012-06)

CD8-mediated virus inhibition can be detected in HIV-1-positive subjects who naturally control virus replication. Characterizing the inhibitory function of CD8(+) T cells during acute HIV-1 infection (AHI) can elucidate ...

Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy.

Bartlett, John A; Crump, John Andrew; Maro, Venance P; Rubach, MP (Am J Trop Med Hyg, 2015-02)

We describe the laboratory-confirmed etiologies of illness among participants in a hospital-based febrile illness cohort study in northern Tanzania who retrospectively met Integrated Management of Adolescent and Adult Illness ...

Etiology of severe non-malaria febrile illness in Northern Tanzania: a prospective cohort study.

Bartlett, John A; Crump, John Andrew; Galloway, RL; Kinabo, GD; Maro, Venance P; Massung, RF; Morrissey, AB; ... (12 authors) (PLoS Negl Trop Dis, 2013)

INTRODUCTION: The syndrome of fever is a commonly presenting complaint among persons seeking healthcare in low-resource areas, yet the public health community has not approached fever in a comprehensive manner. In many areas, ...