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The role of lipid-related genes, aging-related processes, and environment in healthspan.
(Aging Cell, 2013-04)
The inherent complexity of aging-related traits can temper progress in unraveling
the genetic origins of healthspan. We focus on two generations in the Framingham Heart
Study, the original (FHS) and offspring (FHSO) cohorts, ...
Validity of low-intensity continuous renal replacement therapy*.
(Critical care medicine, 2013-11)
OBJECTIVE: To study the hospital mortality of patients with severe acute kidney injury
treated with low-intensity continuous renal replacement therapy. DESIGN: Multicenter
retrospective observational study (Japanese Society ...
Food, class, and health: the role of the perceived body in the social reproduction of health.
(Health communication, 2013-05)
The association between social class and cardiovascular health is complex, involving
a constant interplay of factors as individuals integrate external information from
the media, health care providers, and people they know ...
Polymorphisms in the mTOR gene and risk of sporadic prostate cancer in an Eastern Chinese population.
(PloS one, 2013-01)
BACKGROUND: The mTOR gene regulates cell growth by controlling mRNA translation, ribosome
biogenesis, autophagy, and metabolism. Abnormally increased expression of mTOR was
associated with carcinogenesis, and its functional ...
Polymorphisms of nucleotide excision repair genes predict melanoma survival.
(The Journal of investigative dermatology, 2013-07)
Melanoma is the most highly malignant skin cancer, and nucleotide excision repair
(NER) is involved in melanoma susceptibility. In this analysis of 1,042 melanoma patients,
we evaluated whether genetic variants of NER genes ...
Chikungunya as a cause of acute febrile illness in southern Sri Lanka.
(PLoS One, 2013)
BACKGROUND: Chikungunya virus (CHIKV) re-emerged in Sri Lanka in late 2006 after a
40-year hiatus. We sought to identify and characterize acute chikungunya infection
(CHIK) in patients presenting with acute undifferentiated ...
Gender and age interact to affect early outcome after intracerebral hemorrhage.
(PLoS One, 2013)
BACKGROUND: Intracerebral hemorrhage (ICH) is a common and devastating form of cerebrovascular
disease. In ICH, gender differences in outcomes remain relatively understudied but
have been examined in other neurological ...
Early adoption of dabigatran and its dosing in US patients with atrial fibrillation: results from the outcomes registry for better informed treatment of atrial fibrillation.
(J Am Heart Assoc, 2013-11-25)
BACKGROUND: Dabigatran is a novel oral anticoagulant approved for thromboprophylaxis
in atrial fibrillation. Adoption patterns of this new agent in community practice
are unknown. METHODS AND RESULTS: We studied patterns ...
A risk score for in-hospital death in patients admitted with ischemic or hemorrhagic stroke.
(J Am Heart Assoc, 2013-01-28)
BACKGROUND: We aimed to derive and validate a single risk score for predicting death
from ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage
(SAH). METHODS AND RESULTS: Data from 333 865 stroke ...
Comorbid substance use disorders with other Axis I and II mental disorders among treatment-seeking Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race people.
(Journal of psychiatric research, 2013-12)
Little is known about behavioral healthcare needs of Asian Americans (AAs), Native
Hawaiians/Pacific Islanders (NHs/PIs), and mixed-race people (MRs)-the fastest growing
segments of the U.S. population. We examined substance ...