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Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.
(PLoS Med, 2009-07-07)
BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately
2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally
do not become detectable until 12 weeks ...
Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.
(Br J Cancer, 2009-12-15)
BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant
glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including
27 with glioblastoma (GBM) and 32 with grade ...
Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...
Pseudomonas aeruginosa vesicles associate with and are internalized by human lung epithelial cells.
(BMC Microbiol, 2009-02-03)
BACKGROUND: Pseudomonas aeruginosa is the major pathogen associated with chronic and
ultimately fatal lung infections in patients with cystic fibrosis (CF). To investigate
how P. aeruginosa-derived vesicles may contribute ...
Development of universal antidotes to control aptamer activity.
(Nat Med, 2009-10)
With an ever increasing number of people taking numerous medications, the need to
safely administer drugs and limit unintended side effects has never been greater.
Antidote control remains the most direct means to counteract ...
beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.
(J Clin Invest, 2009-05)
Nicotinic acid is one of the most effective agents for both lowering triglycerides
and raising HDL. However, the side effect of cutaneous flushing severely limits patient
compliance. As nicotinic acid stimulates the GPCR ...
Histone modifications within the human X centromere region.
(PLoS One, 2009-08-12)
Human centromeres are multi-megabase regions of highly ordered arrays of alpha satellite
DNA that are separated from chromosome arms by unordered alpha satellite monomers
and other repetitive elements. Complexities in assembling ...
The toxicology of climate change: environmental contaminants in a warming world.
(Environ Int, 2009-08)
Climate change induced by anthropogenic warming of the earth's atmosphere is a daunting
problem. This review examines one of the consequences of climate change that has only
recently attracted attention: namely, the effects ...
Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.
(Journal of experimental & clinical cancer research : CR, 2009-06-30)
Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these
genes are involved in tumor growth and progression including angiogenesis, dissemination,
and invasiveness, we hypothesized that ...
The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.
(BMC gastroenterology, 2009-10-16)
Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis
of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes
have been associated with risk and progression ...