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    Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. 

    Allgood, S; Amos, JD; Cohen, MS; Eron, JJ; Goepfert, Paul A; Gurley, TC; Haynes, Barton Ford; ... (25 authors) (PLoS Med, 2009-07-07)
    BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks ...
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    Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. 

    Connelly, Jessica J; Crosslin, DR; Crossman, DC; Freedman, NJ; Ginsburg, Geoffrey Steven; Goldschmidt-Clermont, PJ; Granger, CB; ... (22 authors) (PLoS Genet, 2009-01)
    Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up genetic, biostatistical, ...
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    Pseudomonas aeruginosa vesicles associate with and are internalized by human lung epithelial cells. 

    Bauman, SJ; Kuehn, Margarethe Joanna (BMC Microbiol, 2009-02-03)
    BACKGROUND: Pseudomonas aeruginosa is the major pathogen associated with chronic and ultimately fatal lung infections in patients with cystic fibrosis (CF). To investigate how P. aeruginosa-derived vesicles may contribute ...
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    A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. 

    Blackledge, NP; Crawford, Gregory E; Harris, A; Ott, CJ; Suszko, M; Wright, JE (J Cell Mol Med, 2009-04)
    Genes can maintain spatiotemporal expression patterns by long-range interactions between cis-acting elements. The cystic fibrosis transmembrane conductance regulator gene (CFTR) is expressed primarily in epithelial cells. ...
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    Development of universal antidotes to control aptamer activity. 

    Oney, S; Lam, RT; Bompiani, KM; Blake, CM; Quick, G; Heidel, JD; Liu, JY; ... (11 authors) (Nat Med, 2009-10)
    With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to counteract ...
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    Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance. 

    Becher, H; Chierakul, W; Day, NP; Fowler, Vance Garrison Jr; Hongsuwan, M; Limmathurotsakul, D; Mahavanakul, W; ... (16 authors) (PLoS One, 2009)
    BACKGROUND: Most information on invasive Staphylococcus aureus infections comes from temperate countries. There are considerable knowledge gaps in epidemiology, treatment, drug resistance and outcome of invasive S. aureus ...
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    Histone modifications within the human X centromere region. 

    Farr, CJ; Kopf, KS; Mravinac, B; Reeves, JW; Schueler, MG; Sullivan, Beth Ann; Sullivan, LL; ... (8 authors) (PLoS One, 2009-08-12)
    Human centromeres are multi-megabase regions of highly ordered arrays of alpha satellite DNA that are separated from chromosome arms by unordered alpha satellite monomers and other repetitive elements. Complexities in assembling ...
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    Using decision analysis to improve malaria control policy making. 

    Anderson, RM; Dickinson, KL; Fowler, Vance Garrison Jr; Kramer, Randall A; Miranda, Marie Lynn; Mutero, CM; Saterson, KA; ... (8 authors) (Health Policy, 2009-10)
    Malaria and other vector-borne diseases represent a significant and growing burden in many tropical countries. Successfully addressing these threats will require policies that expand access to and use of existing control ...
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    Common genetic variation and the control of HIV-1 in humans. 

    Antonarakis, SE; Beckmann, JS; Carrington, Mary; Castagna, A; Cirulli Rogers, Elizabeth T; Colombo, S; Cozzi-Lepri, A; ... (38 authors) (PLoS Genet, 2009-12)
    To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants ...
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    MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy. 

    Balakumaran, BS; Febbo, PG; Foye, A; Glover, W; Hahn, WC; Hsu, DS; Leung, JY; ... (10 authors) (Cancer Res, 2009-10-01)
    Loss of PTEN and activation of phosphoinositide 3-kinase are commonly observed in advanced prostate cancer. Inhibition of mammalian target of rapamycin (mTOR), a downstream target of phosphoinositide 3-kinase signaling, ...
     

     

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    AuthorFowler, Vance Garrison Jr (2)Haynes, Barton Ford (2)Sullivan, Beth Ann (2)Allgood, S (1)Amos, JD (1)Anderson, RM (1)Antonarakis, SE (1)Balakumaran, BS (1)Bauman, SJ (1)Becher, H (1)... View MoreDate Issued
    2009 (10)
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    Humans (10)
    Male (4)Adult (3)Animals (3)Female (3)Middle Aged (3)Adolescent (2)Alleles (2)Base Sequence (2)Cell Line (2)... View MoreAffiliation of Duke Author(s)
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    School of Medicine (10)Institutes and Centers (9)Clinical Science Departments (8)Duke Cancer Institute (7)Medicine (6)Duke Clinical Research Institute (4)Institutes and Provost's Academic Units (3)... View More