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A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter.
(J Cell Mol Med, 2009-04)
Genes can maintain spatiotemporal expression patterns by long-range interactions between
cis-acting elements. The cystic fibrosis transmembrane conductance regulator gene
(CFTR) is expressed primarily in epithelial cells. ...
Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.
(PLoS Med, 2009-07-07)
BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately
2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally
do not become detectable until 12 weeks ...
MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy.
(Cancer Res, 2009-10-01)
Loss of PTEN and activation of phosphoinositide 3-kinase are commonly observed in
advanced prostate cancer. Inhibition of mammalian target of rapamycin (mTOR), a downstream
target of phosphoinositide 3-kinase signaling, ...
Common genetic variation and the control of HIV-1 in humans.
(PLoS Genet, 2009-12)
To extend the understanding of host genetic determinants of HIV-1 control, we performed
a genome-wide association study in a cohort of 2,554 infected Caucasian subjects.
The study was powered to detect common genetic variants ...
Pseudomonas aeruginosa vesicles associate with and are internalized by human lung epithelial cells.
(BMC Microbiol, 2009-02-03)
BACKGROUND: Pseudomonas aeruginosa is the major pathogen associated with chronic and
ultimately fatal lung infections in patients with cystic fibrosis (CF). To investigate
how P. aeruginosa-derived vesicles may contribute ...
Development of universal antidotes to control aptamer activity.
(Nat Med, 2009-10)
With an ever increasing number of people taking numerous medications, the need to
safely administer drugs and limit unintended side effects has never been greater.
Antidote control remains the most direct means to counteract ...
Histone modifications within the human X centromere region.
(PLoS One, 2009-08-12)
Human centromeres are multi-megabase regions of highly ordered arrays of alpha satellite
DNA that are separated from chromosome arms by unordered alpha satellite monomers
and other repetitive elements. Complexities in assembling ...
Using decision analysis to improve malaria control policy making.
(Health Policy, 2009-10)
Malaria and other vector-borne diseases represent a significant and growing burden
in many tropical countries. Successfully addressing these threats will require policies
that expand access to and use of existing control ...
Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance.
(PLoS One, 2009)
BACKGROUND: Most information on invasive Staphylococcus aureus infections comes from
temperate countries. There are considerable knowledge gaps in epidemiology, treatment,
drug resistance and outcome of invasive S. aureus ...
Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...