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Genetic variations of the ADIPOQgene and risk of prostate cancer in Chinese Han men.
(Asian journal of andrology, 2014-11)
Adiponectin secreted by adipose tissue has been implicated in prostate carcinogenesis.
Genetic variations in ADIPOQ are thought to influence the activity of adiponectin,
thus relating to cancer occurrence. In this hospital-based ...
Potentially functional polymorphisms in the ERCC2 gene and risk of esophageal squamous cell carcinoma in Chinese populations.
(Scientific reports, 2014-01)
ERCC2 is indispensable for nucleotide excision repair pathway, and its functional
polymorphisms may be associated with cancer risk. In a large case-control study of
1126 esophageal squamous cell carcinomas (ESCC) patients ...
A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization.
(Oncotarget, 2014-12)
XRCC4 plays a crucial role in the non-homologous end joining pathway that maintains
genome stability. In this two-stage case-control study with 1,764 non-BRCA1/2 breast
cancer patients and 1,623 cancer-free controls, we ...
Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.
(PloS one, 2014-01)
MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function
as tumor suppressors or oncogenes. Aberrant expression and structural alteration of
microRNAs have been reported to be involved in tumorigenesis ...