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Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. 

Glower, Donald D Jr; Hata, Jonathan Andrew; Koch, Walter J; Kypson, Alan P; Lefkowitz, Robert J; Lilly, R Eric; Pippen, Anne; ... (10 authors) (Circulation, 2000-02-01)
BACKGROUND: Genetic modulation of ventricular function may offer a novel therapeutic strategy for patients with congestive heart failure. Myocardial overexpression of beta(2)-adrenergic receptors (beta(2)ARs) has been shown ...
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The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy. 

Suliman, Hagir B; Carraway, Martha Sue; Ali, Abdelwahid S; Reynolds, Chrystal M; Welty-Wolf, Karen E; Piantadosi, Claude A (J Clin Invest, 2007-12)
The clinical utility of anthracycline anticancer agents, especially doxorubicin, is limited by a progressive toxic cardiomyopathy linked to mitochondrial damage and cardiomyocyte apoptosis. Here we demonstrate that ...
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Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. 

Noma, Takahisa; Lemaire, Anthony; Naga Prasad, Sathyamangla V; Barki-Harrington, Liza; Tilley, Douglas G; Chen, Juhsien; Le Corvoisier, Philippe; ... (11 authors) (J Clin Invest, 2007-09)
Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors (betaARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl ...
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Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. 

Tachibana, Hideo; Naga Prasad, Sathyamangla V; Lefkowitz, Robert J; Koch, Walter J; Rockman, Howard A (Circulation, 2005-02-08)
BACKGROUND: Heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased level of myocardial betaAR kinase 1 (betaARK1). Our previous studies have shown that inhibition ...
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Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. 

Kohout, TA; Takaoka, H; McDonald, PH; Perry, SJ; Mao, L; Lefkowitz, RJ; Rockman, HA (Circulation, 2001-11-13)
BACKGROUND: Stimulation of beta(1)- and beta(2)-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the beta(3)AR is also expressed in the human heart and that its ...
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Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. 

White, DC; Hata, JA; Shah, AS; Glower, DD; Lefkowitz, RJ; Koch, WJ (Proc Natl Acad Sci U S A, 2000-05-09)
When the heart fails, there is often a constellation of biochemical alterations of the beta-adrenergic receptor (betaAR) signaling system, leading to the loss of cardiac inotropic reserve. betaAR down-regulation and functional ...
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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. 

Harding, VB; Jones, LR; Lefkowitz, RJ; Koch, WJ; Rockman, HA (Proc Natl Acad Sci U S A, 2001-05-08)
Chronic human heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased levels of betaAR kinase 1 (betaARK1), which seems critical to the pathogenesis of the disease. ...
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Regulation of G protein-coupled receptor signaling by scaffold proteins. 

Hall, Randy A; Lefkowitz, Robert J (Circ Res, 2002-10-18)
The actions of many hormones and neurotransmitters are mediated through stimulation of G protein-coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with heterotrimeric ...
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Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. 

Eckhart, AD; Duncan, SJ; Penn, RB; Benovic, JL; Lefkowitz, RJ; Koch, WJ (Circ Res, 2000-01-07)
G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors, including alpha(1B)-adrenergic receptors (ARs), resulting in desensitization. In vivo analysis of GRK substrate selectivity has ...
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Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. 

Freeman, K; Lerman, I; Kranias, EG; Bohlmeyer, T; Bristow, MR; Lefkowitz, RJ; Iaccarino, G; ... (9 authors) (J Clin Invest, 2001-04)
The medical treatment of chronic heart failure has undergone a dramatic transition in the past decade. Short-term approaches for altering hemodynamics have given way to long-term, reparative strategies, including beta-adrenergic ...
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AuthorLefkowitz, RJ (7)Koch, WJ (6)Lefkowitz, Robert J (4)Rockman, HA (3)Naga Prasad, Sathyamangla V (2)Rockman, Howard A (2)Shah, AS (2)Ali, Abdelwahid S (1)Baillie, George S (1)Barki-Harrington, Liza (1)... View MoreDate Issued2000 (4)2001 (4)2007 (2)2002 (1)2003 (1)2005 (1)TypeJournal article (13)Subject
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Myocardium (13)
Mice (9)Signal Transduction (7)Cyclic AMP-Dependent Protein Kinases (6)Humans (6)Mice, Transgenic (6)beta-Adrenergic Receptor Kinases (5)Male (4)Protein-Serine-Threonine Kinases (4)... View MoreAffiliation of Duke Author(s)
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Duke (13)Duke Cancer Institute (13)
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Pathology (13)School of Medicine (13)Basic Science Departments (12)Biochemistry (12)Chemistry (12)... View More
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