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Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes.
(PloS one, 2012-01)
In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral
lymphocytes have been shown to be a phenotypic biomarker of individual's DNA repair
phenotype that is associated with cancer risk. In ...
Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy.
(BMC cancer, 2010-08-16)
Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving
in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms
may affect survival outcomes among locally advanced ...
Potentially functional polymorphisms in the ERCC2 gene and risk of esophageal squamous cell carcinoma in Chinese populations.
(Scientific reports, 2014-01)
ERCC2 is indispensable for nucleotide excision repair pathway, and its functional
polymorphisms may be associated with cancer risk. In a large case-control study of
1126 esophageal squamous cell carcinomas (ESCC) patients ...
Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.
(BMC cancer, 2011-06-20)
Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase
family plays crucial roles in carcinogenesis and progression of several cancers, including
squamous cell carcinoma of the head and neck ...
Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck.
(BMC cancer, 2012-05)
The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and
myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human
papillomavirus 16 (HPV16), by inducing p53 and pRb-E2F ...
Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.
(Molecular carcinogenesis, 2018-01)
Metzincins are key molecules in the degradation of the extracellular matrix and play
an important role in cellular processes such as cell migration, adhesion, and cell
fusion of malignant tumors, including cutaneous melanoma ...
Association of Common Genetic Polymorphisms with Melanoma Patient IL-12p40 Blood Levels, Risk, and Outcomes.
(J Invest Dermatol, 2015-09)
Recent investigation has identified association of IL-12p40 blood levels with melanoma
recurrence and patient survival. No studies have investigated associations of single-nucleotide
polymorphisms (SNPs) with melanoma patient ...
Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study.
(BMC Med Genet, 2010-01-19)
BACKGROUND: Several studies have noted that genetic variants of SCARB1, a lipoprotein
receptor involved in reverse cholesterol transport, are associated with serum lipid
levels in a sex-dependent fashion. However, the mechanism ...
Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
(Tumour Biol, 2015-09)
The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of
apoptosis and the transformation and progression of malignant cells. Genetic variations
in KIF1B may contribute to risk of epithelial ovarian ...
Genetic variants in the TEP1 gene are associated with prostate cancer risk and recurrence.
(Prostate Cancer Prostatic Dis, 2015-12)
BACKGROUND: Telomere-related genes play an important role in carcinogenesis and progression
of prostate cancer (PCa). It is not fully understood whether genetic variations in
telomere-related genes are associated with development ...