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The Danish Twin Registry: linking surveys, national registers, and biological information.

Bingley, P; Christensen, Kaare; Christiansen, L; Hjelmborg, J; Holm, NV; Hvidberg, L; Kyvik, KO; ... (13 authors) (Twin Res Hum Genet, 2013-02)

Over the last 60 years, the resources and the research in the Danish Twin Registry (DTR) have periodically been summarized. Here, we give a short overview of the DTR and a more comprehensive description of new developments ...

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Soerensen, M; Dato, S; Tan, Q; Thinggaard, M; Kleindorp, R; Beekman, M; Jacobsen, R; ... (19 authors) (Exp Gerontol, 2012-05)

Here we explore association with human longevity of common genetic variation in three major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidants by investigating 1273 tagging ...

Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.

Christensen, Kaare; Franceschi, Claudio; Honig, LS; Kirkwood, TBL; McGue, M; Passarino, G; Pedersen, JK; ... (10 authors) (Ann Epidemiol, 2015-08)

PURPOSE: Familial clustering of longevity is well documented and includes both genetic and other familial factors, but the specific underlying mechanisms are largely unknown. We examined whether low incidence of specific ...

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.

Soerensen, M; Dato, S; Tan, Q; Thinggaard, M; Kleindorp, R; Beekman, M; Suchiman, HED; ... (19 authors) (Age (Dordr), 2013-04)

In this study, we investigated 102 single-nucleotide polymorphisms (SNPs) covering the common genetic variation in 16 genes recurrently regarded as candidates for human longevity: APOE; ACE; CETP; HFE; IL6; IL6R; MTHFR; ...

Physical and mental decline and yet rather happy? A study of Danes aged 45 and older.

Christensen, Kaare; Jeune, B; McGue, M; Thinggaard, M; Vaupel, James Walton; Vestergaard, S (Aging Ment Health, 2015)

OBJECTIVES: Little is known about whether the feeling of happiness follows the age-related decline in physical and mental functioning. The objective of this study was to analyze differences with age in physical and mental ...

DNA methylation age is associated with mortality in a longitudinal Danish twin study.

Aviv, A; Christensen, Kaare; Christiansen, L; Lenart, A; McGue, M; Tan, Q; Vaupel, James Walton (Aging Cell, 2016-02)

An epigenetic profile defining the DNA methylation age (DNAm age) of an individual has been suggested to be a biomarker of aging, and thus possibly providing a tool for assessment of health and mortality. In this study, ...