Now showing items 1-5 of 5
FGF23/FGFR4-mediated left ventricular hypertrophy is reversible.
(Scientific reports, 2017-05-16)
Fibroblast growth factor (FGF) 23 is a phosphaturic hormone that directly targets cardiac myocytes via FGF receptor (FGFR) 4 thereby inducing hypertrophic myocyte growth and the development of left ventricular hypertrophy ...
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.
(Cancer discovery, 2017-04)
BRAF drives tumorigenesis by coordinating the activation of the RAS/RAF/MEK/ERK oncogenic signaling cascade. However, upstream pathways governing BRAF kinase activity and protein stability remain undefined. Here, we report ...
Hybrid spectral CT reconstruction.
(PLoS One, 2017)
Current photon counting x-ray detector (PCD) technology faces limitations associated with spectral fidelity and photon starvation. One strategy for addressing these limitations is to supplement PCD data with high-resolution, ...
Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.
(Nature immunology, 2017-09)
The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity. Notably, two ...
IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense.
(The Journal of investigative dermatology, 2017-05)
Skin wound repair requires a coordinated program of epithelial cell proliferation and differentiation as well as resistance to invading microbes. However, the factors that trigger epithelial cell proliferation in ...