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Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.

DeVito, Nicholas; Locasale, Jason; Hanks, Brent; Nair, Smita; Zhao, Fei; Xiao, Christine; Evans, Kathy S; ... (12 authors) (Immunity, 2018-01)

Despite recent advances, many cancers remain refractory to available immunotherapeutic strategies. Emerging evidence indicates that the tolerization of local dendritic cells (DCs) within the tumor microenvironment promotes ...

DOK2 inhibits EGFR-mutated lung adenocarcinoma.

Chen, Ming; Berger, Alice H; Morotti, Alessandro; Janas, Justyna A; Niki, Masaru; Bronson, Roderick T; Taylor, Barry S; ... (12 authors) (PloS one, 2013-01)

Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas and the importance of EGFR mutations for the initiation and maintenance of lung cancer is well established from mouse models and cancer ...

Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.

Burlingham, WJ; Farris, AB; Knechtle, Stuart J; Kwun, J; Mahle, WT; Song, H (Transplantation, 2015-12)

BACKGROUND: Blocking leukocyte function-associated antigen (LFA)-1 in organ transplant recipients prolongs allograft survival. However, the precise mechanisms underlying the therapeutic potential of LFA-1 blockade in preventing ...

A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data.

Badea, Alexandra; Calabrese, Evan; Cofer, Gary P; Johnson, G Allan; Qi, Y (Cereb Cortex, 2015-11)

Interest in structural brain connectivity has grown with the understanding that abnormal neural connections may play a role in neurologic and psychiatric diseases. Small animal connectivity mapping techniques are particularly ...

Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia.

Arumugam, Ramamani; Brooks, ED; Curtis, S; Demaster, A; Freemark, Michael Scott; Jackson, MW; Kishnani, Priya Sunil; ... (11 authors) (Mol Genet Metab, 2013-06)

Glycogen Storage Disease type Ia (GSD-Ia) in humans frequently causes delayed bone maturation, decrease in final adult height, and decreased growth velocity. This study evaluates the pathogenesis of growth failure and the ...

Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.

Andrade, ZA; Chan, IS; Choi, SS; Diehl, Anna Mae; Lambertucci, JR; Machado, MV; Otoni, A; ... (19 authors) (Clin Sci (Lond), 2015-11)

Schistosomiasis is a major cause of portal hypertension worldwide. It associates with portal fibrosis that develops during chronic infection. The mechanisms by which the pathogen evokes these host responses remain unclear. ...

MRP3: a molecular target for human glioblastoma multiforme immunotherapy.

Bigner, DD; Herndon, James Emmett II; Kuan, Chien-Tsun; Lipp, Eric S; McLendon, Roger E; Pegram, CN; Rasheed, A; ... (11 authors) (BMC Cancer, 2010-09-01)

BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies. To overcome the problem of heterogeneity, more brain tumor markers are required for prognosis and targeted therapy. We have identified and ...

Interleukin-15 receptor blockade in non-human primate kidney transplantation.

Faure, JP; Fechner, J; Haustein, S; Kayaoglu, A; Knechtle, Stuart J; Kwun, J; Roenneburg, D; ... (8 authors) (Transplantation, 2010-04-27)

BACKGROUND: Interleukin (IL)-15 is a chemotactic factor to T cells. It induces proliferation and promotes survival of activated T cells. IL-15 receptor blockade in mouse cardiac and islet allotransplant models has led to ...

Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage.

Dawson, Hana Nenicka; James, Michael Lucas; Laskowitz, Daniel Todd; Lei, Beilei; Roulhac-Wilson, B; Wang, Haichen (J Neuroinflammation, 2013-08-20)

BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized by a prominent neuroinflammatory response. Antagonism of pro-inflammatory cytokines by specific antibodies represents a compelling ...

Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate.

Ament, JJ; Budin, F; Cofer, Gary P; Everson, JL; Holloway, HT; Johnson, G Allan; Lipinski, RJ; ... (10 authors) (PLoS One, 2014)

Subtle behavioral and cognitive deficits have been documented in patient cohorts with orofacial clefts (OFCs). Recent neuroimaging studies argue that these traits are associated with structural brain abnormalities but have ...