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Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia.
(Mol Genet Metab, 2013-06)
Glycogen Storage Disease type Ia (GSD-Ia) in humans frequently causes delayed bone
maturation, decrease in final adult height, and decreased growth velocity. This study
evaluates the pathogenesis of growth failure and the ...
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
(PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus
aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential
phenotype are unknown. Using chromosome ...
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
(Nature genetics, 2018-02)
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer.
Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate
cancer (CaP). We demonstrated that conditional ...
Preclinical and Coclinical Studies in Prostate Cancer.
(Cold Spring Harbor perspectives in medicine, 2018-04-02)
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably
succumb to their disease. Thus there remains a pressing need for preclinical testing
of new drugs and drug combinations for late-stage ...
Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models.
(The Journal of pathology, 2012-01)
Squamous metaplasia (SQM) is a specific phenotype in response to oestrogen in the
prostate and oestrogen receptor (ER) α is required to mediate this response. Previous
studies utilizing tissue recombination with seminal ...
Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal.
(PLoS Pathog, 2014-08)
Ongoing Cryptococcus gattii outbreaks in the Western United States and Canada illustrate
the impact of environmental reservoirs and both clonal and recombining propagation
in driving emergence and expansion of microbial ...
Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate.
(PLoS One, 2014)
Subtle behavioral and cognitive deficits have been documented in patient cohorts with
orofacial clefts (OFCs). Recent neuroimaging studies argue that these traits are associated
with structural brain abnormalities but have ...
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.
(Skeletal muscle, 2018-12-27)
BACKGROUND:β2-adrenergic receptors (β2ARs) are the target of catecholamines and play
fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An
important action of β2AR stimulation on skeletal muscle ...
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...