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Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.
(PLoS One, 2011)
OBJECTIVE: Chronic fibrosing liver injury is a major risk factor for hepatocarcinogenesis
in humans. Mice with targeted deletion of Mdr2 (the murine ortholog of MDR3) develop
chronic fibrosing liver injury. Hepatocellular ...
Extended-release ranolazine: critical evaluation of its use in stable angina.
(Vasc Health Risk Manag, 2011)
Coronary heart disease is the major cause of morbidity and mortality throughout the
world, and is responsible for approximately one of every six deaths in the US. Angina
pectoris is a clinical syndrome characterized ...
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
(J Immunol, 2011-03-15)
Stimulated CD4(+) T lymphocytes can differentiate into effector T cell (Teff) or inducible
regulatory T cell (Treg) subsets with specific immunological roles. We show that Teff
and Treg require distinct metabolic programs ...
Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.
(PLoS Pathog, 2011-09)
During many chronic infections virus-specific CD8 T cells succumb to exhaustion as
they lose their ability to respond to antigenic activation. Combinations of IL-12,
IL-18, and IL-21 have been shown to induce the ...
Transmission of MRSA between companion animals and infected human patients presenting to outpatient medical care facilities.
(PLoS One, 2011)
Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen in both
human and veterinary medicine. The importance of companion animals as reservoirs of
human infections is currently unknown. The companion ...
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.
(J Immunol, 2011-10-15)
T cell activation leads to engagement of cellular metabolic pathways necessary to
support cell proliferation and function. However, our understanding of the signal
transduction pathways that regulate metabolism and their ...
Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation.
(J Immunol, 2011-10-15)
Grafts can be rejected even when matched for MHC because of differences in the minor
histocompatibility Ags (mH-Ags). H4- and H60-derived epitopes are known as immunodominant
mH-Ags in H2(b)-compatible BALB.B to C57BL/6 ...
Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism.
(PLoS One, 2011)
Normally, neutrophil pools are maintained by homeostatic mechanisms that require the
transcription factor C/EBPα. Inflammation, however, induces neutrophilia through a
distinct pathway of "emergency" granulopoiesis that ...
Characterization of basal pseudopod-like processes in ileal and colonic PYY cells.
(J Mol Histol, 2011-02)
The peptide tyrosine tyrosine (PYY) is produced and secreted from L cells of the gastrointestinal
mucosa. To study the anatomy and function of PYY-secreting L cells, we developed a
transgenic PYY-green fluorescent protein ...
Membrane binding of plasmid DNA and endocytic pathways are involved in electrotransfection of mammalian cells.
(PLoS One, 2011)
Electric field mediated gene delivery or electrotransfection is a widely used method
in various studies ranging from basic cell biology research to clinical gene therapy.
Yet, mechanisms of electrotransfection are still ...