Browsing Scholarly Articles by Affiliation of Duke Author(s) "Surgery, Cardiovascular and Thoracic Surgery"
Now showing items 1-20 of 37
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An isolated working heart system for large animal models.
(J Vis Exp, 2014-06-11)Since its introduction in the late 19(th) century, the Langendorff isolated heart perfusion apparatus, and the subsequent development of the working heart model, have been invaluable tools for studying cardiovascular function ... -
Aspergillus niger: an unusual cause of invasive pulmonary aspergillosis.
(J Med Microbiol, 2010-07)Infections due to Aspergillus species cause significant morbidity and mortality. Most are attributed to Aspergillus fumigatus, followed by Aspergillus flavus and Aspergillus terreus. Aspergillus niger is a mould that is ... -
Assessment of Coronary Blood Flow by Transesophageal Echocardiography.
(J Cardiothorac Vasc Anesth, 2016-01) -
Atheromatous disease of the aorta and perioperative stroke.
(J Thorac Cardiovasc Surg, 2017-09-14) -
Benefit of adjuvant chemotherapy after resection of stage II (T1-2N1M0) non-small cell lung cancer in elderly patients.
(Ann Surg Oncol, 2015-02)BACKGROUND: We evaluated the use and efficacy of adjuvant chemotherapy after resection of T1-2N1M0 non-small cell lung cancer (NSCLC) in elderly patients. METHODS: Factors associated with the use of adjuvant chemotherapy ... -
Bleeding and the new anticoagulants: Strategies and concerns
(Anesthesiology, 2015-01-01) -
Clopidogrel use After Myocardial Revascularization: Prevalence, Predictors, and One-Year Survival Rate.
(Braz J Cardiovasc Surg, 2016-04)INTRODUCTION: Antiplatelet therapy after coronary artery bypass graft (CABG) has been used. Little is known about the predictors and efficacy of clopidogrel in this scenario. OBJECTIVE: Identify predictors of clopidogrel ... -
Does surgery improve outcomes for esophageal squamous cell carcinoma? An analysis using the surveillance epidemiology and end results registry from 1998 to 2008.
(J Am Coll Surg, 2012-11)BACKGROUND: We examined survival associated with locally advanced esophageal squamous cell cancer (SCC) to evaluate if treatment without surgery could be considered adequate. STUDY DESIGN: Patients in the Surveillance, ... -
Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.
(J Clin Invest, 1996-04-01)To assess the effect of targeted myocardial beta-adrenergic receptor (AR) stimulation on relaxation and phospholamban regulation, we studied the physiological and biochemical alterations associated with overexpression of ... -
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
(J Clin Invest, 1999-07)Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic strategy for treatment of cardiovascular diseases such as heart failure (HF). Before gene therapy approaches to alter cardiac function ... -
Evidence that SOX2 overexpression is oncogenic in the lung.
(PLoS One, 2010-06-10)BACKGROUND: SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed in some solid tumors, and is expressed in epithelial cells of the lung. METHODOLOGY/PRINCIPAL FINDINGS: We show that SOX2 is ... -
Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.
(Kidney Int, 2015-10)Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following ... -
Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery.
(BMJ Open, 2015-05-06)OBJECTIVES: Identification of patient subpopulations susceptible to develop myocardial infarction (MI) or, conversely, those displaying either intrinsic cardioprotective phenotypes or highly responsive to protective interventions ... -
In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.
(Circulation, 2001-03-06)BACKGROUND: Genetic manipulation to reverse molecular abnormalities associated with dysfunctional myocardium may provide novel treatment. This study aimed to determine the feasibility and functional consequences of in vivo ... -
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
(Circulation, 2000-02-01)BACKGROUND: Genetic modulation of ventricular function may offer a novel therapeutic strategy for patients with congestive heart failure. Myocardial overexpression of beta(2)-adrenergic receptors (beta(2)ARs) has been shown ... -
Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.
(Proc Natl Acad Sci U S A, 1997-01-07)Transgenic overexpression (40- to 100-fold) of the wild-type human beta2-adrenergic receptor in the hearts of mice leads to a marked increase in cardiac contractility, which is apparently due to the low level of spontaneous ... -
Longitudinal Changes in Regional Cerebral Perfusion and Cognition Following Cardiac Surgery.
(The Annals of thoracic surgery, 2018-09-22)Cardiac surgery has been associated with increased risk of postoperative cognitive decline, as well as dementia risk in the general population. Few studies, however, have examined the impact of coronary revascularization ... -
Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest.
(J Thorac Cardiovasc Surg, 2017-01)OBJECTIVE: Aortic surgeries requiring hypothermic circulatory arrest evoke systemic inflammatory responses that often manifest as vasoplegia and hypotension. Because mast cells can rapidly release vasoactive and proinflammatory ... -
Mitral Regurgitation After Orthotopic Lung Transplantation: Natural History and Impact on Outcomes.
(J Cardiothorac Vasc Anesth, 2017-06)OBJECTIVE: Progression of mitral regurgitation (MR) after orthotopic lung transplantation (OLT) may be an underrecognized phenomenon due to the overlapping symptomatology of pulmonary and valvular disease. Literature evaluating ...
