Now showing items 1-1 of 1

    • Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. 

      Yan, Hai; Lopez, Giselle; Koivunen, Peppi; Lee, Sungwoo; Duncan, Christopher G; Lu, Gang; Ramkissoon, Shakti; ... (17 authors) (Nature, 2012-02-15)
      The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the idea that altered cellular metabolism can transform cells. Inactivating ...