Browsing Scholarly Articles by Author "Rabbani, ZN"

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Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response.

Ashcraft, K; Boruta, RJ; Cao, Y; Dewhirst, Mark Wesley; Dreher, MR; Eble, J; Fels, D; ... (18 authors) (PLoS One, 2013)

Resistance of hypoxic solid tumor niches to chemotherapy and radiotherapy remains a major scientific challenge that calls for conceptually new approaches. Here we exploit a hitherto unrecognized ability of sickled erythrocytes ...
Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation.

Dewhirst, Mark Wesley; Herndon, James Emmett II; Rabbani, ZN; Vlahovic, G; Vujaskovic, Z (Br J Cancer, 2006-10-23)

Elevated intratumoral interstitial fluid pressure (IFP) and tumour hypoxia are independent predictive factors for poor survival and poor treatment response in cancer patients. However, the relationship between IFP and tumour ...