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Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data.
(Biogerontology, 2011-04)
Small sample size of genetic data is often a limiting factor for desirable accuracy
of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic
data containing information on survival or disease ...
Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.
(Mech Ageing Dev, 2010-05)
The Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic
receptor (ADRB2) gene appears to be associated with a broad range of aging-associated
phenotypes, including cancers at different sites, ...
Trade-offs between cancer and other diseases: do they exist and influence longevity?
(Rejuvenation Res, 2010-08)
Relationships between aging, disease risks, and longevity are not yet well understood.
For example, joint increases in cancer risk and total survival observed in many human
populations and some experimental aging studies ...
Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.
(Rejuvenation Res, 2015-04)
The lack of evolutionary established mechanisms linking genes to age-related traits
makes the problem of genetic susceptibility to health span inherently complex. One
complicating factor is genetic trade-off. Here we focused ...
How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.
(Biogerontology, 2016-02)
Increasing proportions of elderly individuals in developed countries combined with
substantial increases in related medical expenditures make the improvement of the
health of the elderly a high priority today. If the process ...
Inter-chromosomal level of genome organization and longevity-related phenotypes in humans.
(Age (Dordr), 2013-04)
Studies focusing on unraveling the genetic origin of health span in humans assume
that polygenic, aging-related phenotypes are inherited through Mendelian mechanisms
of inheritance of individual genes. We use the Framingham ...
The role of lipid-related genes, aging-related processes, and environment in healthspan.
(Aging Cell, 2013-04)
The inherent complexity of aging-related traits can temper progress in unraveling
the genetic origins of healthspan. We focus on two generations in the Framingham Heart
Study, the original (FHS) and offspring (FHSO) cohorts, ...
Age trajectories of physiological indices in relation to healthy life course.
(Mech Ageing Dev, 2011-03)
We analysed relationship between the risk of onset of "unhealthy life" (defined as
the onset of cancer, cardiovascular diseases, or diabetes) and longitudinal changes
in body mass index, diastolic blood pressure, hematocrit, ...
Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction.
(Rejuvenation Res, 2010-02)
Multiple functions of the beta2-adrenergic receptor (ADRB2) and angiotensin-converting
enzyme (ACE) genes warrant studies of their associations with aging-related phenotypes.
We focus on multimarker analyses and analyses ...
Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.
(J Gerontol A Biol Sci Med Sci, 2013-07)
This study focuses on the participants of the Long Life Family Study to elucidate
whether biogenetic mechanisms underlying relationships among heritable complex phenotypes
in parents function in the same way for the same ...