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Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
(J Clin Invest, 1999-07)
Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic
strategy for treatment of cardiovascular diseases such as heart failure (HF). Before
gene therapy approaches to alter cardiac function ...
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
(Proc Natl Acad Sci U S A, 2000-05-09)
When the heart fails, there is often a constellation of biochemical alterations of
the beta-adrenergic receptor (betaAR) signaling system, leading to the loss of cardiac
inotropic reserve. betaAR down-regulation and functional ...
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
(Circulation, 2000-02-01)
BACKGROUND: Genetic modulation of ventricular function may offer a novel therapeutic
strategy for patients with congestive heart failure. Myocardial overexpression of
beta(2)-adrenergic receptors (beta(2)ARs) has been shown ...