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Reprint of ''Using neuroimaging to individualize TMS treatment for depression: Toward a new paradigm for imaging-guided intervention''.
(NeuroImage, 2017-05)
The standard clinical technique for using repetitive transcranial magnetic stimulation
(rTMS) for major depressive disorder (MDD) is associated with limited efficacy to
date. Such limited efficacy may be due to reliance ...
Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases.
(Genetics in medicine : official journal of the American College of Medical Genetics, 2018-04)
PurposeTo describe examples of missed pathogenic variants on whole-exome sequencing
(WES) and the importance of deep phenotyping for further diagnostic testing.MethodsGuided
by phenotypic information, three children with ...
A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor.
(Frontiers in oncology, 2018-01)
Olfactory receptor OR51E2, also known as a Prostate Specific G-Protein Receptor, is
highly expressed in prostate cancer but its function is not well understood. Through
in silico and in vitro analyses, we identified 24 agonists ...
Longitudinal Changes in Regional Cerebral Perfusion and Cognition Following Cardiac Surgery.
(The Annals of thoracic surgery, 2018-09-22)
Cardiac surgery has been associated with increased risk of postoperative cognitive
decline, as well as dementia risk in the general population. Few studies, however,
have examined the impact of coronary revascularization ...
Perspectives on genetic and genomic technologies in an academic medical center: the duke experience.
(Journal of personalized medicine, 2015-04-03)
In this age of personalized medicine, genetic and genomic testing is expected to become
instrumental in health care delivery, but little is known about its actual implementation
in clinical practice.We surveyed Duke faculty ...
Effect of Prenatal Smoke Exposure on Birth Weight: The Moderating Role of Maternal Depressive Symptoms.
(Nicotine & tobacco research : official journal of the Society for Research on Nicotine
and Tobacco, 2018-12-24)
Introduction:Both prenatal smoke exposure and depression have been linked to lower
birth weight, a risk factor for morbidity and mortality. Few studies have looked at
the interaction between these risk factors and none have ...
The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.
(Journal of the American Geriatrics Society, 2019-01-23)
BACKGROUND/OBJECTIVES:Every year, up to 40% of the more than 16 million older Americans
who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD)
or delirium. Each of these distinct syndromes is associated ...
Validation of the Sleep Regularity Index in Older Adults and Associations with Cardiometabolic Risk.
(Scientific reports, 2018-09-21)
Sleep disturbances, including insufficient sleep duration and circadian misalignment,
confer risk for cardiometabolic disease. Less is known about the association between
the regularity of sleep/wake schedules and cardiometabolic ...
Pre-Pregnancy Weight and Symptoms of Attention Deficit Hyperactivity Disorder and Executive Functioning Behaviors in Preschool Children.
(International journal of environmental research and public health, 2019-02-25)
This study examines pre-pregnancy Body Mass Index (BMI) and gestational weight gain
(GWG) in relation to early childhood Attention Deficit Hyperactivity Disorder (ADHD)
symptoms and related executive self-regulation behaviors. ...
Cannabinoid exposure and altered DNA methylation in rat and human sperm.
(Epigenetics, 2018-01)
Little is known about the reproductive effects of paternal cannabis exposure. We evaluated
associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA
methylation in sperm from humans and ...