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    Host gene expression classifiers diagnose acute respiratory illness etiology. 

    Burke, T; Cairns, CB; Carin, Lawrence; Fowler, Vance Garrison Jr; Freeman, DH; Ginsburg, Geoffrey Steven; Glickman, Seth W; ... (24 authors) (Sci Transl Med, 2016-01-20)
    Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ...
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    Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans. 

    Burke, T; Chakraborty, S; Ginsburg, Geoffrey Steven; Harro, CD; McClain, MT; Nicholson, BP; Sack, DA; ... (11 authors) (J Infect Dis, 2016-05-01)
    BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is a globally prevalent cause of diarrhea. Though usually self-limited, it can be severe and debilitating. Little is known about the host transcriptional response to infection. ...
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    Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 

    Ahn, SH; Cairns, CB; Cyr, Derek; Fowler, Vance Garrison Jr; Ginsburg, Geoffrey Steven; Glickman, Seth W; Kingsmore, Stephen F; ... (17 authors) (PLoS One, 2013)
    Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ...
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    Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients. 

    Chu, Vivian Hou; Fowler, Vance Garrison Jr; Ginsburg, Geoffrey Steven; Glickman, Seth W; Himmel, T; Hudson, LL; Katz, JN; ... (14 authors) (Ann Am Thorac Soc, 2016-03)
    RATIONALE: Limitations in methods for the rapid diagnosis of hospital-acquired infections often delay initiation of effective antimicrobial therapy. New diagnostic approaches offer potential clinical and cost-related improvements ...
     

     

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    Ginsburg, Geoffrey Steven (4)
    Tsalik, Ephraim L (4)
    Woods, Christopher Wildrick (4)Fowler, Vance Garrison Jr (3)Glickman, Seth W (3)McClain, MT (3)Burke, T (2)Cairns, CB (2)Hudson, LL (2)Kingsmore, Stephen F (2)... View MoreDate Issued2016 (3)2013 (1)TypeJournal article (4)SubjectAdult (4)
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    Middle Aged (4)Young Adult (4)Aged (3)Aged, 80 and over (3)Female (3)Host-Pathogen Interactions (3)Male (3)Gene Expression Profiling (2)... View MoreAffiliation of Duke Author(s)Biomedical Engineering (4)Clinical Science Departments (4)
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    Duke Cancer Institute (4)Global Health Institute (4)Institutes and Centers (4)Institutes and Provost's Academic Units (4)
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    Medicine, Cardiology (4)Medicine, Infectious Diseases (4)... View More